Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

Hypertension, characterised by a constant high blood pressure, is the primary risk factor for
multiple cardiovascular events and a major cause of death in adults. Excitingly, innovations …

Document Reviewers: Luis Alcocer (Mexico), Christina Antza (Greece), Mustafa Arici
(Turkey), Eduardo Barbosa (Brazil), Adel Berbari (Lebanon), Luıs Bronze (Portugal), John …

The role of rare non-coding variation in complex human phenotypes is still largely unknown.
To elucidate the impact of rare variants in regulatory elements, we performed a whole …

Background Hypertension (HTN) is the leading cause of cardiovascular disease morbidity
and mortality worldwide. Despite effective treatments, most people with HTN do not have …

Genome-wide association studies of blood pressure (BP) have identified> 1,000 loci, but the
effector genes and biological pathways at these loci are mostly unknown. Using published …

The role of rare non-coding variation in complex human phenotypes is still largely unknown.
To elucidate the impact of rare variants in regulatory elements, we performed a whole …

Objective Hypertension has long been recognized as one of the most important
predisposing factors for cardiovascular diseases and mortality. In recent years, machine …

Background Despite the use of Next-Generation Sequencing (NGS) as the gold standard for
the diagnosis of rare diseases, its clinical implementation has been challenging, limiting the …

Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established
predictor of coronary artery disease (CAD) events. Here we describe a genome-wide …