Artificial Intelligence (AI) is making a profound impact in almost every domain. A vital enabler
of its great success is the availability of abundant and high-quality data for building machine …

Most proteins in cells are composed of multiple folding units (or domains) to perform
complex functions in a cooperative manner. Relative to the rapid progress in single-domain …

The human microbiome is an integral component of the human body and a co-determinant
of several health conditions,. However, the extent to which interpersonal relations shape the …

AlphaFold2 revolutionized structural biology with the ability to predict protein structures with
exceptionally high accuracy. Its implementation, however, lacks the code and data required …

Metagenomic assembly enables new organism discovery from microbial communities, but it
can only capture few abundant organisms from most metagenomes. Here we present …

Abstract AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …

Protein design aims to build novel proteins customized for specific purposes, thereby
holding the potential to tackle many environmental and biomedical problems. Recent …

We consider the problem of predicting a protein sequence from its backbone atom
coordinates. Machine learning approaches to this problem to date have been limited by the …

Fecal microbiota transplantation (FMT) is highly effective against recurrent Clostridioides
difficile infection and is considered a promising treatment for other microbiome-related …

Bacterial anti-phage systems are frequently clustered in microbial genomes, forming
defense islands. This property enabled the recent discovery of multiple defense systems …