Towards organoid culture without Matrigel

MT Kozlowski, CJ Crook, HT Ku - Communications biology, 2021 - nature.com
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Self-assembling peptide EAK16 and RADA16 nanofiber scaffold hydrogel

F Gelain, Z Luo, S Zhang - Chemical reviews, 2020 - ACS Publications
Short peptides are ubiquitous in nature. They are found as hormones, pheromones,
antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But …

Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Synthetic extracellular matrices with function-encoding peptides

C Ligorio, A Mata - Nature reviews bioengineering, 2023 - nature.com
The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …

[HTML][HTML] Biomaterials to enhance stem cell transplantation

BN Kharbikar, P Mohindra, TA Desai - Cell Stem Cell, 2022 - cell.com
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes

J Xu, S Fang, S Deng, H Li, X Lin, Y Huang… - Nature Biomedical …, 2023 - nature.com
Organoids with region-specific architecture could facilitate the repair of injuries of the central
nervous system. Here we show that human astrocytes can be directly reprogrammed into …

Self-assembling peptide scaffolds in the clinic

F Gelain, Z Luo, M Rioult, S Zhang - NPJ Regenerative medicine, 2021 - nature.com
Well-defined scaffold hydrogels made of self-assembling peptides have found their way into
clinical products. By examining the properties and applications of two self-assembling …

Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury

H Geng, Z Li, Z Li, Y Zhang, Z Gao… - Proceedings of the …, 2023 - National Acad Sciences
Spinal cord injury (SCI) can lead to iron overloading and subsequent neuronal ferroptosis,
which hinders the recovery of locomotor function. However, it is still unclear whether the …

Designer self‐assembling peptide hydrogels to engineer 3D cell microenvironments for cell constructs formation and precise oncology remodeling in ovarian cancer

Z Yang, H Xu, X Zhao - Advanced Science, 2020 - Wiley Online Library
Designer self‐assembling peptides form the entangled nanofiber networks in hydrogels by
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …

[HTML][HTML] Injectable hydrogels for spinal cord injury repair

H Wang, H Zhang, Z **e, K Chen, M Ma, Y Huang… - Engineered …, 2022 - Elsevier
Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a
huge burden to the patient and the whole society. Many strategies, especially biomaterials …