Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Self-assembling peptide EAK16 and RADA16 nanofiber scaffold hydrogel
Short peptides are ubiquitous in nature. They are found as hormones, pheromones,
antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But …
antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But …
Transplanting neural progenitor cells to restore connectivity after spinal cord injury
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …
individuals and society. The goal of research in this field is to find a means of restoring lost …
Synthetic extracellular matrices with function-encoding peptides
The communication of cells with their surroundings is mostly encoded in the epitopes of
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …
structural and signalling proteins present in the extracellular matrix (ECM). These peptide …
[HTML][HTML] Biomaterials to enhance stem cell transplantation
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …
medicine approaches and open promising avenues to repair, replace, and regenerate …
Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes
J Xu, S Fang, S Deng, H Li, X Lin, Y Huang… - Nature Biomedical …, 2023 - nature.com
Organoids with region-specific architecture could facilitate the repair of injuries of the central
nervous system. Here we show that human astrocytes can be directly reprogrammed into …
nervous system. Here we show that human astrocytes can be directly reprogrammed into …
Self-assembling peptide scaffolds in the clinic
Well-defined scaffold hydrogels made of self-assembling peptides have found their way into
clinical products. By examining the properties and applications of two self-assembling …
clinical products. By examining the properties and applications of two self-assembling …
Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury
H Geng, Z Li, Z Li, Y Zhang, Z Gao… - Proceedings of the …, 2023 - National Acad Sciences
Spinal cord injury (SCI) can lead to iron overloading and subsequent neuronal ferroptosis,
which hinders the recovery of locomotor function. However, it is still unclear whether the …
which hinders the recovery of locomotor function. However, it is still unclear whether the …
Designer self‐assembling peptide hydrogels to engineer 3D cell microenvironments for cell constructs formation and precise oncology remodeling in ovarian cancer
Z Yang, H Xu, X Zhao - Advanced Science, 2020 - Wiley Online Library
Designer self‐assembling peptides form the entangled nanofiber networks in hydrogels by
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …
ionic‐complementary self‐assembly. This type of hydrogel has realistic biological and …
[HTML][HTML] Injectable hydrogels for spinal cord injury repair
Spinal cord injury (SCI) often causes severe functional impairment of body, which leads to a
huge burden to the patient and the whole society. Many strategies, especially biomaterials …
huge burden to the patient and the whole society. Many strategies, especially biomaterials …