Increasing appreciation of the phenotypic and biological overlap between amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence …

Abstract The National Institute on Aging and the Alzheimer's Association convened three
separate work groups in 2011 and single work groups in 2012 and 2018 to create …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of upper and lower motor neurons. The heterogeneous nature of …

Importance Biomarkers are lacking that can discriminate frontotemporal lobar degeneration
(FTLD) associated with tau (FTLD-tau) or TDP-43 (FTLD-TDP). Objective To test whether …

Abstract Objective Within Lewy body spectrum disorders (LBSD) with α‐synuclein pathology
(αSyn), concomitant Alzheimer's disease (AD) pathology is common and is predictive of …

Previous studies have suggested that systemic viral infections may increase risks of
dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 …

Blood-based biomarkers for Alzheimer's disease (AD) pathology have been intensively
investigated as markers for AD-related neurodegeneration. Comorbid AD pathology is …

Recent literature suggests that markers of neuroaxonal damage, such as neurofilaments
and tau protein, might serve as potential biomarkers for ALS. We conducted this systematic …

The health and well-being of retired rugby union and league players, particularly regarding
the long-term effects of concussions, are of major concern. Concussion has been identified …

INTRODUCTION Fluid biomarkers capable of specifically tracking tau tangle pathology in
vivo are greatly needed. METHODS We measured cerebrospinal fluid (CSF) and plasma …