Microorganisms are remarkable chemists, with enzymes as their tools for executing multi-
step syntheses to yield myriad natural products. Microbial synthetic aptitudes are illustrated …

Mining microbial genomes including those of Streptomyces reveals the presence of a large
number of biosynthetic gene clusters. Unraveling this genetic potential has proved to be a …

Cyclodipeptide synthases (CDPSs) can catalyze the formation of two successive peptide
bonds by hijacking aminoacyl-tRNAs from the ribosomal machinery resulting in …

Heterologous expression in Streptomyces coelicolor and in vitro enzyme characterization
proved that two P450 enzymes, AspB and NasB, from Streptomyces sp. NRRL S-1868 …

Heterologous expression of a three-gene cluster from Streptomyces aurantiacus coding for a
cyclodipeptide synthase, a prenyltransferase, and a methyltransferase led to the elucidation …

While several marine natural products bearing the 2, 5-diketopiperazine ring have been
reported to date, the unique chemistry of dimeric frameworks appears to remain neglected …

Tailoring enzymes are important modification biocatalysts in natural product biosynthesis.
We report herein six orthologous two‐gene clusters for mycocyclosin and guatyromycine …

A cyclo-l-Trp-l-Trp tailoring P450 with novel function from Streptomyces purpureus was
identified by heterologous expression in S. coelicolor and in vitro assays the recombinant …

Cyclodipeptides from fungi and bacteria are often modified by different tailoring enzymes.
They display various biological and pharmacological activities, and some derivatives are …

Genome mining revealed the presence of two cdps-p450 operons in Saccharopolyspora
antimicrobica. Heterologous expression, biochemical characterisation and structure …