Therapeutic potential of N-methyl-D-aspartate receptor modulators in psychiatry
JE Hanson, H Yuan, RE Perszyk, TG Banke… - …, 2024 - nature.com
Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …
synaptic transmission, are widely distributed throughout the central nervous system, and …
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research
S Lv, K Yao, Y Zhang, S Zhu - Neuropharmacology, 2023 - Elsevier
Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
Molecular mechanism of ligand gating and opening of NMDA receptor
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
means by which neurons control their excitability and neuroplasticity. The N-methyl-d …
Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs
Neurotransmission mediated by diverse subtypes of N-methyl-D-aspartate receptors
(NMDARs) is fundamental for basic brain functions and development as well as …
(NMDARs) is fundamental for basic brain functions and development as well as …
Allosteric inhibition of NMDA receptors by low dose ketamine
JA Abbott, H Wen, B Liu, SS Gupta, GJ Iacobucci… - Molecular …, 2024 - nature.com
Ketamine, a general anesthetic, has rapid and sustained antidepressant effects when
administered at lower doses. Anesthetic levels of ketamine reduce excitatory transmission …
administered at lower doses. Anesthetic levels of ketamine reduce excitatory transmission …
Structural insights into NMDA receptor pharmacology
C Zhou, N Tajima - Biochemical Society Transactions, 2023 - portlandpress.com
N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …
Subtype-specific conformational landscape of NMDA receptor gating
J Bleier, PRF de Mendonca, CH Habrian, C Stanley… - Cell reports, 2024 - cell.com
N-methyl-D-aspartate receptors are ionotropic glutamate receptors that mediate synaptic
transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with …
transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with …
Structural and functional mechanisms of anti-NMDAR autoimmune encephalitis
Autoantibodies against neuronal membrane proteins can manifest in autoimmune
encephalitis, inducing seizures, cognitive dysfunction and psychosis. Anti-N-methyl-d …
encephalitis, inducing seizures, cognitive dysfunction and psychosis. Anti-N-methyl-d …
GluN2A and GluN2B N-Methyl-D-Aspartate receptor (NMDARs) subunits: their roles and therapeutic antagonists in neurological diseases
N-methyl-d-aspartate receptors (NMDARs) are ion channels that respond to the
neurotransmitter glutamate, playing a crucial role in the permeability of calcium ions and …
neurotransmitter glutamate, playing a crucial role in the permeability of calcium ions and …
Structural insights into gating mechanism and allosteric regulation of NMDA receptors
N-methyl-d-aspartate receptors (NMDARs) belong to the ionotropic glutamate receptors
(iGluRs) superfamily and act as coincidence detectors that are crucial to neuronal …
(iGluRs) superfamily and act as coincidence detectors that are crucial to neuronal …