We herein present an overview of the upcoming 5th edition of the World Health Organization
Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid …

Several editions of the World Health Organization (WHO) classifications of lympho-
hemopoietic neoplasms in 2001, 2008 and 2017 served as the international standard for …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

The historical lack of preclinical models reflecting the genetic heterogeneity of multiple
myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this …

Multiple myeloma (MM) is consistently preceded by precursor conditions recognized
clinically as monoclonal gammopathy of undetermined significance (MGUS) or smoldering …

The term 'precancer'typically refers to an early stage of neoplastic development that is
distinguishable from normal tissue owing to molecular and phenotypic alterations, resulting …

Abstract Deciphering Multiple Myeloma evolution in the whole bone marrow is key to inform
curative strategies. Here, we perform spatial-longitudinal whole-exome sequencing …

Patients with smoldering multiple myeloma (SMM) are observed until progression, but early
treatment may improve outcomes. We conducted a phase II trial of elotuzumab …

Background: Multiple myeloma is the second most common hematologic malignancy, which
to date remains incurable despite advances in treatment strategies including the use of …

Plasma cell neoplasms including multiple myeloma (MM) and related terminally
differentiated B-cell neoplasms are characterized by secretion of monoclonal …