Tumours progress through a cascade of events that enable the formation of metastases.
Some of the components that are required for this fatal process are well established …

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …

TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1
Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated …

Amyloid precursor protein (APP) has eight potential phosphorylation sites in its cytoplasmic
domain. Recently, it has demonstrated that the constitutive phosphorylation of APP at T668 …

Tetraspanin KAI1/CD82 is a wide-spectrum tumor metastasis suppressor. KAI1/CD82
suppresses tumor metastasis by primarily inhibiting cancer cell motility and invasiveness. In …

Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …

Homologues of nucleosome assembly protein 1 (NAP1) have been identified in all
eukaryotes. Although initially identified as histone chaperones and chromatin-assembly …

Amyloid precursor protein (APP) metabolites (amyloid-β (Aβ) peptides) and Tau are the
main components of senile plaques and neurofibrillary tangles, the two histopathological …

Presenilins (PS, PS1/PS2) are necessary for the proteolytic activity of γ-secretase, which
cleaves multiple type I transmembrane proteins including Alzheimer's β-amyloid precursor …