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[HTML][HTML] AKT/PKB signaling: navigating the network
The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
Dopamine receptors–IUPHAR R eview 13
The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
The physiology, signaling, and pharmacology of dopamine receptors
G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from …
Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …
recognized a promising drug discovery target in treating multiple pathological conditions …
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
BACKGROUND: Despite widely reported clinical and preclinical studies of rapid
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists …
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists …
TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice
Recovery from major depressive disorder is difficult, particularly in patients who are
refractory to antidepressant treatments. To examine factors that regulate recovery, we …
refractory to antidepressant treatments. To examine factors that regulate recovery, we …
Long-term depression in the CNS
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …
process that may be involved in learning and memory and in various pathological …
GSK-3: functional insights from cell biology and animal models
Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved
serine/threonine protein kinase encoded in mammals by two genes that generate two …
serine/threonine protein kinase encoded in mammals by two genes that generate two …
Circadian rhythm disturbances in mood disorders: insights into the role of the suprachiasmatic nucleus
Circadian rhythm disturbances are a common symptom among individuals with mood
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …
disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior …