Depression is a prevalent, complex, and highly debilitating disease. The full comprehension
of this disease is still a global challenge. Indeed, relapse, recurrency, and therapeutic …

Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

The rodent hippocampus generates new neurons throughout life. This process, named adult
hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Adult hippocampal neurogenesis declines in aging rodents and primates. Aging humans are
thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting …

Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Whether hippocampal neurogenesis persists throughout life in the human brain is not fully
resolved. Here, we demonstrate that hippocampal neurogenesis is persistent through the …

Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by
environmental influences, and functionally implicated in behavioural responses to stress …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …