Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements

S Her, DA Jaffray, C Allen - Advanced drug delivery reviews, 2017 - Elsevier
Gold nanoparticles (AuNPs) have emerged as novel radiosensitizers owing to their high X-
ray absorption, synthetic versatility, and unique chemical, electronic and optical properties …

Gold nanoparticles as radiosensitizers in cancer radiotherapy

Y Chen, J Yang, S Fu, J Wu - International Journal of …, 2020 - Taylor & Francis
The rapid development of nanotechnology offers a variety of potential therapeutic strategies
for cancer treatment. High atomic element nanomaterials are often utilized as …

Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

MA Bernal, MC Bordage, JMC Brown, M Davídková… - Physica Medica, 2015 - Elsevier
Understanding the fundamental mechanisms involved in the induction of biological damage
by ionizing radiation remains a major challenge of today's radiobiology research. The Monte …

Gold nanoparticles as a potent radiosensitizer: A transdisciplinary approach from physics to patient

S Penninckx, AC Heuskin, C Michiels, S Lucas - Cancers, 2020 - mdpi.com
Over the last decade, a growing interest in the improvement of radiation therapies has led to
the development of gold-based nanomaterials as radiosensitizer. Although the …

Nanoparticle radio-enhancement: principles, progress and application to cancer treatment

Z Kuncic, S Lacombe - Physics in Medicine & Biology, 2018 - iopscience.iop.org
Enhancement of radiation effects by high-atomic number nanoparticles (NPs) has been
increasingly studied for its potential to improve radiotherapeutic efficacy. The underlying …

Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

J Schuemann, AF Bagley, R Berbeco… - Physics in Medicine …, 2020 - iopscience.iop.org
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of
radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z= 22, to …

Size-tuning ionization to optimize gold nanoparticles for simultaneous enhanced CT imaging and radiotherapy

Y Dou, Y Guo, X Li, X Li, S Wang, L Wang, G Lv… - ACS …, 2016 - ACS Publications
Computed tomography (CT) contrast and radiosensitization usually increase with particle
sizes of gold nanoparticles (AuNPs), but there is a huge challenge to improve both by …

Roadmap to clinical use of gold nanoparticles for radiation sensitization

J Schuemann, R Berbeco, DB Chithrani, SH Cho… - International Journal of …, 2016 - Elsevier
The past decade has seen a dramatic increase in interest in the use of gold nanoparticles
(GNPs) as radiation sensitizers for radiation therapy. This interest was initially driven by their …

Enhancement of radiosensitization by silver nanoparticles functionalized with polyethylene glycol and aptamer As1411 for glioma irradiation therapy

J Zhao, P Liu, J Ma, D Li, H Yang… - International journal of …, 2019 - Taylor & Francis
Background The efficacy of radiotherapy for glioma is often limited by the radioresistance of
glioma cells. The radiosensitizing effects of silver nanoparticles (AgNPs) on glioma were …

Prospects of nanoparticle-based radioenhancement for radiotherapy

LRH Gerken, ME Gerdes, M Pruschy… - Materials horizons, 2023 - pubs.rsc.org
Radiotherapy is a key pillar of solid cancer treatment. Despite high level of conformal dose
deposition, radiotherapy is limited due to co-irradiation of organs-at risk and subsequent …