Early molecular markers for retrospective biodosimetry and prediction of acute health effects

M Abend, WF Blakely, P Ostheim… - Journal of …, 2022 - iopscience.iop.org
Radiation-induced biological changes occurring within hours and days after irradiation can
be potentially used for either exposure reconstruction (retrospective dosimetry) or the …

Gene expression for biodosimetry and effect prediction purposes: promises, pitfalls and future directions–key session ConRad 2021

P Ostheim, SA Amundson, C Badie… - … journal of radiation …, 2022 - Taylor & Francis
Purpose In a nuclear or radiological event, an early diagnostic or prognostic tool is needed
to distinguish unexposed from low-and highly exposed individuals with the latter requiring …

Lung transcriptome of nonhuman primates exposed to total-and partial-body irradiation

NN Vellichirammal, S Sethi, S Pandey, J Singh… - … Therapy-Nucleic Acids, 2022 - cell.com
The focus of radiation biodosimetry has changed recently, and a paradigm shift for using
molecular technologies of omic platforms in addition to cytogenetic techniques has been …

RENEB Inter-laboratory comparison 2021: Inter-assay comparison of eight dosimetry assays

M Port, JF Barquinero, D Endesfelder… - Radiation …, 2023 - meridian.allenpress.com
Tools for radiation exposure reconstruction are required to support the medical management
of radiation victims in radiological or nuclear incidents. Different biological and physical …

RENEB inter-laboratory comparison 2021: the gene expression assay

M Abend, SA Amundson, C Badie… - Radiation …, 2023 - meridian.allenpress.com
Early and high-throughput individual dose estimates are essential following large-scale
radiation exposure events. In the context of the Running the European Network for …

Transcriptome profile changes in the jejunum of nonhuman primates exposed to supralethal dose of total-or partial-body radiation

NN Vellichirammal, S Sethi, N Avuthu, SY Wise… - BMC genomics, 2023 - Springer
The risk of exposure of the general public or military personnel to high levels of ionizing
radiation from nuclear weapons or radiological accidents is a dire national security matter …

Impact of radiation therapy on healthy tissues

C Chargari, E Rassy, C Helissey, S Achkar… - International review of …, 2023 - Elsevier
Radiation therapy has a fundamental role in the management of cancers. However, despite
a constant improvement in radiotherapy techniques, the issue of radiation-induced side …

[HTML][HTML] Radiation-induced gene expression changes used for biodosimetry and clinical outcome prediction: challenges and promises

M Abend, P Ostheim, M Port - Cytogenetic and Genome Research, 2023 - karger.com
As the war in Ukraine progresses, the radiological and nuclear threat has never been as real
as now. The formation of life-threatening acute radiation syndrome (ARS), in particular after …

Four genes predictive for the severity of hematological damage reveal a similar response after X irradiation and chemotherapy

S Schüle, EA Bristy, R Muhtadi, G Kaletka… - Radiation …, 2023 - meridian.allenpress.com
Radiological and especially nuclear accidents and incidents pose a threat to populations. In
such events, gene expression (GE) analysis of a set of 4 genes (FDXR, DDB2, POU2AF1 …

The Influence of Computed Tomography Contrast Agent on Radiation-Induced Gene Expression and Double-Strand Breaks

S Schüle, F Bunert, C Hackenbroch… - Radiation …, 2024 - meridian.allenpress.com
After nuclear scenarios, combined injuries of acute radiation syndrome (ARS) with, eg,
abdominal trauma, will occur and may require contrast-enhanced computed tomography …