Peptic ulcer, affecting 10% of the global population, results from imbalances in gastric juice
pH and diminished mucosal defences. Key underlying factors are non-steroidal anti …

Ethnopharmacological relevance When exacerbated, inflammatory processes can culminate
in physical and emotional disorders and, if not stopped, can be lethal. The high prevalence …

Abstract Apoptosis signal kinase 1 (ASK 1) is a member of the mitogen-activated protein
kinase (MAPK) family that induces cells apoptosis including colorectal cancer (CRC). CRC …

Type 2 diabetes mellitus remains global health challenge with involvement of both insulin
resistance and dysfunctional insulin secretion from the pancreatic β-cell. Currently …

Diabetes is a metabolic disease characterized by high blood glucose (hyperglycemia)
resulting from insulin deficiency, insulin resistance, or both. 1 Diabetes mellitus (DM) is …

Studies have established the pharmacological properties of Blighia sapida especially the
glucose lowering potential without the elucidation of its mechanism of action. A negative …

Compounds derived from natural sources continue to serve as chemical scaffolds for
designing prophylactic/therapeutic options for human healthcare. In this study, we aimed to …

Abstract The Ethyl Acetate Fraction (EACF) of Ethanol Leaf Extract of Vitellaria paradoxa
(ELVp) was assessed against Sodium Arsenite (SA)-induced toxicity in Drosophila …

Human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an enzyme that catalyzes
the generation of active cortisol from cortisone, thus regulating the availability of …

The balance between oxidant production and their conversion to harmless products is vital
to the survival of living organisms. Hence the comparative free radical scavenging activity of …