Multiple sclerosis: mechanisms and immunotherapy

C Baecher-Allan, BJ Kaskow, HL Weiner - Neuron, 2018 - cell.com
Multiple sclerosis (MS) is an autoimmune disease triggered by environmental factors that act
on a genetically susceptible host. It features three clinical stages: a pre-clinical stage …

Mechanism-based criteria to improve therapeutic outcomes in progressive multiple sclerosis

HYF Yong, VW Yong - Nature Reviews Neurology, 2022 - nature.com
In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

The role of astrocytes in multiple sclerosis

G Ponath, C Park, D Pitt - Frontiers in immunology, 2018 - frontiersin.org
The role traditionally assigned to astrocytes in the pathogenesis of multiple sclerosis (MS)
lesions has been the formation of the glial scar once inflammation has subsided. Astrocytes …

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

CS Constantinescu, N Farooqi… - British journal of …, 2011 - Wiley Online Library
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Multiple sclerosis: pathogenesis and treatment

I Loma, R Heyman - Current neuropharmacology, 2011 - ingentaconnect.com
Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the
central nervous system. It affects approximately 400,000 people in the United States and …

Cladribine: mode of action and implications for treatment of multiple sclerosis

TP Leist, R Weissert - Clinical neuropharmacology, 2011 - journals.lww.com
Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the central nervous
system. The inflammation is driven significantly by autoreactive lymphocytes, which recruit …

[PDF][PDF] Impact of diagnosis and early treatment on the course of multiple sclerosis

K Noyes, B Weinstock-Guttman - Am J Manag Care, 2013 - ajmc.s3.amazonaws.com
Impact of Diagnosis and Early Treatment on the Course of Multiple Sclerosis Page 1 VOL. 19, NO.
17 ■ THE AMERICAN JOURNAL OF MANAGED CARE ■ S321 Multiple sclerosis (MS), a …

New approaches in the management of multiple sclerosis

LJ Barten, DR Allington, KA Procacci… - Drug design …, 2010 - Taylor & Francis
Multiple sclerosis (MS) is a central nervous system chronic inflammatory disease that is
characterized by an extensive and complex immune response. Scientific advances have …

Teriflunomide for multiple sclerosis

D He, C Zhang, X Zhao, Y Zhang… - … of systematic reviews, 2016 - cochranelibrary.com
Teriflunomide for multiple sclerosis - He, D - 2016 | Cochrane Library Skip to Content
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Update on immununosuppressive therapies for dogs and cats

KR Viviano - Veterinary Clinics: Small Animal Practice, 2013 - vetsmall.theclinics.com
The body's immune system is essential for protecting it from a variety of pathogens and other
external insults. It is through the complex interactions between the cells and mediators of …