CGRP as the target of new migraine therapies—successful translation from bench to clinic
Abstract Treatment of migraine is on the cusp of a new era with the development of drugs
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …
Calcitonin gene-related peptide: physiology and pathophysiology
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …
Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
P Holzer - Neuroscience, 1988 - Elsevier
5. LOCAL EFFECTOR FUNCTIONS OF SENSORY NERVE ENDINGS 743 50.1. Antidromic
Vas~ iIatation, neurogenic inflammation and axon refk~ 5.0. 2. The type of sensory neurons …
Vas~ iIatation, neurogenic inflammation and axon refk~ 5.0. 2. The type of sensory neurons …
CGRP may play a causative role in migraine
LH Lassen, PA Haderslev, VB Jacobsen… - …, 2002 - journals.sagepub.com
Calcitonin gene-related peptide (CGRP) has been detected in increased amounts in
external jugular venous blood during migraine attacks. However, it is unknown whether this …
external jugular venous blood during migraine attacks. However, it is unknown whether this …
Vascular actions of calcitonin gene-related peptide and adrenomedullin
SD Brain, AD Grant - Physiological reviews, 2004 - journals.physiology.org
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
Regulation of the cerebral circulation: role of endothelium and potassium channels
FM Faraci, DD Heistad - Physiological reviews, 1998 - journals.physiology.org
Faraci, Frank M., and Donald D. Heistad. Regulation of the Cerebral Circulation: Role of
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …
Endothelium and Potassium Channels. Physiol. Rev. 78: 53–97, 1998.—Several new …
Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells
TF McDonald, S Pelzer, W Trautwein… - Physiological …, 1994 - journals.physiology.org
I. OVERVIEW AND NOMENCLATURE Times change. In 1926, the writer of a review in this
journal noted that over 350 papers had appeared on the subject during the previous 2 years …
journal noted that over 350 papers had appeared on the subject during the previous 2 years …
T he T rigeminovascular P athway: R ole of CGRP and CGRP R eceptors in M igraine
L Edvinsson - Headache: The Journal of Head and Face Pain, 2017 - Wiley Online Library
The trigeminal ganglion plays a key role in primary headache pathophysiology. Calcitonin
gene‐related peptide (CGRP) and CGRP receptors are expressed in trigeminal neurons that …
gene‐related peptide (CGRP) and CGRP receptors are expressed in trigeminal neurons that …
The trigeminovascular system in humans: pathophysiologic implications for primary headache syndromes of the neural influences on the cerebral circulation
Primary headache syndromes, such as cluster headache and migraine, are widely
described as vascular headaches, although considerable clinical evidence suggests that …
described as vascular headaches, although considerable clinical evidence suggests that …
CGRP and its receptors provide new insights into migraine pathophysiology
Over the past 300 years, the migraine field has been dominated by two main theories—the
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …