In 2013, we published a set of clinical practice recommendations for the treatment of Alport
syndrome in this journal. We recommended delaying the initiation of angiotensin-converting …

The glomerular basement membrane is a vital component of the filtration barrier of the
kidney and is primarily composed of a highly structured matrix of type IV collagen. Specific …

Background The reported prevalence of Alport syndrome varies from one in 5000 to one in
53,000 individuals. This study estimated the frequencies of predicted pathogenic COL4A3 …

Genetic testing for pathogenic COL4A3–5 variants is usually undertaken to investigate the
cause of persistent hematuria, especially with a family history of hematuria or kidney function …

Background Alport syndrome is a genetic disorder characterized by a defective glomerular
basement membrane, tubulointerstitial fibrosis, inflammation, and progressive renal failure …

Col4a3−/− Alport mice serve as an animal model for renal fibrosis. MicroRNA-21 (miR-21)
expression has been shown to be increased in the kidneys of Alport syndrome patients …

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Objectives: Differentiate gross hematuria and microscopic hematuria. Implement evidence-
based protocols for the evaluation of patients with gross and microscopic hematuria. Select …

Alport syndrome (AS) is a progressive inherited kidney disease characterized by hearing
loss and ocular abnormalities. There are three forms of AS depending on inheritance mode …

Background: Hypertension, endothelial dysfunction, and inflammation are associated with
increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of …