Effects of selection at linked sites on patterns of genetic variability
B Charlesworth, JD Jensen - Annual review of ecology …, 2021 - annualreviews.org
Patterns of variation and evolution at a given site in a genome can be strongly influenced by
the effects of selection at genetically linked sites. In particular, the recombination rates of …
the effects of selection at genetically linked sites. In particular, the recombination rates of …
[PDF][PDF] How can we resolve Lewontin's paradox?
B Charlesworth, JD Jensen - Genome biology and evolution, 2022 - academic.oup.com
We discuss the genetic, demographic, and selective forces that are likely to be at play in
restricting observed levels of DNA sequence variation in natural populations to a much …
restricting observed levels of DNA sequence variation in natural populations to a much …
Efficient ancestry and mutation simulation with msprime 1.0
Stochastic simulation is a key tool in population genetics, since the models involved are
often analytically intractable and simulation is usually the only way of obtaining ground-truth …
often analytically intractable and simulation is usually the only way of obtaining ground-truth …
Inferring the Demographic History of Aye-Ayes (Daubentonia madagascariensis) from High-Quality, Whole-Genome, Population-Level Data
The nocturnal aye-aye, Daubentonia madagascariensis, is one of the most elusive lemurs
on the island of Madagascar. The timing of its activity and arboreal lifestyle has generally …
on the island of Madagascar. The timing of its activity and arboreal lifestyle has generally …
Modeling SARS-CoV-2 spike/ACE2 protein–protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related …
Aims The rapid spread of new SARS-CoV-2 variants has highlighted the crucial role played
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …
in the infection by mutations occurring at the SARS-CoV-2 spike receptor binding domain …
Inferring demographic and selective histories from population genomic data using a two-step approach in species with coding-sparse genomes: an application to …
The demographic history of a population, and the distribution of fitness effects (DFE) of
newly arising mutations in functional genomic regions, are fundamental factors dictating …
newly arising mutations in functional genomic regions, are fundamental factors dictating …
Sweepstakes reproductive success via pervasive and recurrent selective sweeps
Highly fecund natural populations characterized by high early mortality abound, yet our
knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap …
knowledge about their recruitment dynamics is somewhat rudimentary. This knowledge gap …
Develo** an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples
Over the past 3 years, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
has spread through human populations in several waves, resulting in a global health crisis …
has spread through human populations in several waves, resulting in a global health crisis …
SARS-CoV-2 entry into and evolution within a skilled nursing facility
SARS-CoV-2 belongs to the family Coronaviridae which includes multiple human pathogens
that have an outsized impact on aging populations. As a novel human pathogen, SARS-CoV …
that have an outsized impact on aging populations. As a novel human pathogen, SARS-CoV …
A simulation framework for modeling the within-patient evolutionary dynamics of SARS-CoV-2
The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
led to considerable interest in detecting novel beneficial mutations and other genomic …
led to considerable interest in detecting novel beneficial mutations and other genomic …