Recent developments in antimalarial activities of 4-aminoquinoline derivatives

L Ravindar, SA Hasbullah, KP Rakesh… - European Journal of …, 2023 - Elsevier
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …

Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics

H Madhav, E Jameel, M Rehan, N Hoda - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …

Potential of nanoformulations in malaria treatment

JB Chaves, B Portugal Tavares de Moraes… - Frontiers in …, 2022 - frontiersin.org
Malaria is caused by the protozoan Plasmodium sp and affects millions of people worldwide.
Its clinical form ranges from asymptomatic to potentially fatal and severe. Current treatments …

New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations

AA Bekhit, ET Lodebo, A Hymete… - Journal of enzyme …, 2022 - Taylor & Francis
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

OPS Patel, RM Beteck, LJ Legoabe - European journal of medicinal …, 2021 - Elsevier
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …

A brief overview of classical natural product drug synthesis and bioactivity

G Li, M Lou, X Qi - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Traditional medicines consisting of compounds derived from natural organisms have been
used for human health care worldwide since ancient times. Since the last century, huge …

Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria …

H Madhav, TS Patel, Z Rizvi, GS Reddy… - European Journal of …, 2023 - Elsevier
Malaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …

A Three-Step Catalytic Asymmetric Sequence from Alkynes to α-Silyloxyaldehydes and Its Application to a C22–C41 Fragment of Bastimolide A

JN Hackbarth, GK Friestad - Organic letters, 2024 - ACS Publications
1, 5-Polyol structures present challenges in stereocontrol, configurational assignment, and
diastereomer separation; these are all compromised by remote stereochemical …

[HTML][HTML] Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity

D Stopper, LP de Carvalho, ML de Souza… - European Journal of …, 2024 - Elsevier
Dynamics of epigenetic modifications such as acetylation and deacetylation of histone
proteins have been shown to be crucial for the life cycle development and survival of …

In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy

IO Evbuomwan, OO Alejolowo, TC Elebiyo… - Journal of …, 2024 - Taylor & Francis
The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …