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Recent developments in antimalarial activities of 4-aminoquinoline derivatives
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties …
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …
degeneration of the central nervous system, resulting in memory loss and cognitive …
Potential of nanoformulations in malaria treatment
JB Chaves, B Portugal Tavares de Moraes… - Frontiers in …, 2022 - frontiersin.org
Malaria is caused by the protozoan Plasmodium sp and affects millions of people worldwide.
Its clinical form ranges from asymptomatic to potentially fatal and severe. Current treatments …
Its clinical form ranges from asymptomatic to potentially fatal and severe. Current treatments …
New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations
AA Bekhit, ET Lodebo, A Hymete… - Journal of enzyme …, 2022 - Taylor & Francis
Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …
in vivo antimalarial activities of new pyrazolylpyrazoline derivatives against Plasmodium …
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research
Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
the genus Plasmodium. It caused an estimated 405,000 deaths and 228 million malaria …
A brief overview of classical natural product drug synthesis and bioactivity
G Li, M Lou, X Qi - Organic Chemistry Frontiers, 2022 - pubs.rsc.org
Traditional medicines consisting of compounds derived from natural organisms have been
used for human health care worldwide since ancient times. Since the last century, huge …
used for human health care worldwide since ancient times. Since the last century, huge …
Development of diphenylmethylpiperazine hybrids of chloroquinoline and triazolopyrimidine using Petasis reaction as new cysteine proteases inhibitors for malaria …
Malaria is a widespread infectious disease, causing nearly 247 million cases in 2021. The
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
absence of a broadly effective vaccine and rapidly decreasing effectiveness of most of the …
A Three-Step Catalytic Asymmetric Sequence from Alkynes to α-Silyloxyaldehydes and Its Application to a C22–C41 Fragment of Bastimolide A
JN Hackbarth, GK Friestad - Organic letters, 2024 - ACS Publications
1, 5-Polyol structures present challenges in stereocontrol, configurational assignment, and
diastereomer separation; these are all compromised by remote stereochemical …
diastereomer separation; these are all compromised by remote stereochemical …
[HTML][HTML] Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity
D Stopper, LP de Carvalho, ML de Souza… - European Journal of …, 2024 - Elsevier
Dynamics of epigenetic modifications such as acetylation and deacetylation of histone
proteins have been shown to be crucial for the life cycle development and survival of …
proteins have been shown to be crucial for the life cycle development and survival of …
In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy
The emergence of varying levels of resistance to currently available antimalarial drugs
significantly threatens global health. This factor heightens the urgency to explore bioactive …
significantly threatens global health. This factor heightens the urgency to explore bioactive …