Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Does it matter that rodents used as preclinical models of human biology are routinely
housed below their thermoneutral zone? We compile evidence showing that such rodents …

Mammals, including humans, prepare for sleep by nesting and/or curling up, creating
microclimates of skin warmth. To address whether external warmth induces sleep through …

Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

One of the major challenges the scientific community faces today is the lack of translational
data generated from mouse trials for human health application. Housing temperature …

There is increasing evidence that cardiovascular control during sleep is relevant for
cardiovascular risk. This evidence warrants increased experimental efforts to understand the …

Background Changes in autonomic control cause regular breathing during NREM sleep to
fluctuate during REM. Piezoelectric cage-floor sensors have been used to successfully …

Obstructive sleep apnea (OSA) is a common disorder that describes recurrent collapse of
the upper airway during sleep. Animal models have been pivotal to the understanding of …

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia and is associated with
significant morbidity and mortality. Obstructive sleep apnoea (OSA) is common among …

Orexins (OX-A and OX-B), also referred to as hypocretin 1 and 2, are neuropeptides
synthesized by neurons located in the perifornical and lateral regions of the hypothalamus …