HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …

Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …

While CD4+ T cell depletion is key to disease progression in people living with HIV and SIV-
infected macaques, the mechanisms underlying this depletion remain incompletely …

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to
suppress antiviral immune responses. Here, we show that the accessory viral protein U …

Different host proteins target different HIV proteins and antagonize their functions,
depending on the stage of the HIV life cycle and the stage of infection. Concurrently, HIV …

HIV emerged following cross-species transmissions of simian immunodeficiency viruses
(SIVs) that naturally infect non-human primates (NHPs) from Africa. While HIV replication …

Summary Background Viremic non-progressors (VNPs) represent an exceptional and
uncommon subset of people with HIV-1, characterized by the remarkable preservation of …

Human immunodeficiency virus (HIV)-1 and HIV-2 originated from cross-species
transmission of simian immunodeficiency viruses (SIVs). Most of these transfers resulted in …

Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection.
Here, we examined how this outcome is achieved by comparing a natural SIV host, African …

Unlike HIV infection, SIV infection is generally nonpathogenic in natural hosts, such as
African green monkeys (AGMs), despite life-long high viral replication. Lack of disease …