IBD disease-modifying therapies: insights from emerging therapeutics
Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …
Harnessing polymer-derived drug delivery systems for combating inflammatory bowel disease
Y Pu, X Fan, Z Zhang, Z Guo, Q Pan, W Gao… - Journal of Controlled …, 2023 - Elsevier
The inflammatory bowel disease (IBD) is incurable, chronic, recrudescent disorders in the
inflamed intestines. Current clinic treatments are challenged by systemic exposure-induced …
inflamed intestines. Current clinic treatments are challenged by systemic exposure-induced …
An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …
X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …
Ultrathin hafnium disulfide atomic crystals with ROS-scavenging and colon-targeting capabilities for inflammatory bowel disease treatment
The exciting success of NBTXR3 in the clinic has triggered a tumult of activities in the design
and development of hafnium-based nanoparticles. However, due to the concerns of …
and development of hafnium-based nanoparticles. However, due to the concerns of …
Nanoassemblies derived from natural flavonoid compounds as new antioxidant oral preparations for targeted inflammatory bowel disease therapy
N Tang, Z Ding, S Zhang, D Luo, X Liu… - Advanced Functional …, 2023 - Wiley Online Library
Possessing the largest surface area of mucosa in the body, the gastrointestinal (GI) tract can
easily sufferfrom inflammatory damage under various adverse external exposures, resulting …
easily sufferfrom inflammatory damage under various adverse external exposures, resulting …
Research status of dendrimer micelles in tumor therapy for drug delivery
X Wang, M Zhang, Y Li, H Cong, B Yu, Y Shen - Small, 2023 - Wiley Online Library
Dendrimers are a family of polymers with highly branched structure, well‐defined
composition, and extensive functional groups, which have attracted great attention in …
composition, and extensive functional groups, which have attracted great attention in …
Injectable bioadhesive hydrogels scavenging ROS and restoring mucosal barrier for enhanced ulcerative colitis therapy
D Li, J Li, T Chen, X Qin, L Pan, X Lin… - … Applied Materials & …, 2023 - ACS Publications
Despite the progress in the therapy of ulcerative colitis (UC), long-lasting UC remission can
hardly be achieved in the majority of UC patients. The key pathological characteristics of UC …
hardly be achieved in the majority of UC patients. The key pathological characteristics of UC …
Gram-scale preparation of quercetin supramolecular nanoribbons for intestinal inflammatory diseases by oral administration
W Sun, Y Chen, L Wang, Z Wang, S Liu, M Zhang… - Biomaterials, 2023 - Elsevier
Gastrointestinal (GI) tract, which possesses the largest surface area of mucosa in the body,
is easily suffered from inflammatory damages under the exposure of external stimulations …
is easily suffered from inflammatory damages under the exposure of external stimulations …
Bio-adhesive and ROS-scavenging hydrogel microspheres for targeted ulcerative colitis therapy
Q Sun, J Chen, Q Zhao, Z He, L Tang, Y Pu… - International Journal of …, 2023 - Elsevier
Ulcerative colitis (UC) as an important type of inflammatory bowel disease is a chronic
disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the …
disease characterized by intestinal dyshomeostasis. The UC treatment is challenged by the …
Orally administrated olsalazine-loaded multilayer pectin/chitosan/alginate composite microspheres for ulcerative colitis treatment
J Li, Y Pu, S Li, B He, J Chen - Biomacromolecules, 2023 - ACS Publications
The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC)
and Crohn's disease is extremely cloudy. Maintaining the level of remission lesions in colitis …
and Crohn's disease is extremely cloudy. Maintaining the level of remission lesions in colitis …