Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective
therapy for ocular diseases, especially for the posterior segment, has been considered as a …

Background: Intravitreal injection (IVI) with administration of various pharmacological agents
is a mainstay of treatment in ophthalmology for endopthalmitis, viral retinitis, age-related …

Purpose.: To determine the pharmacokinetics and pharmacodynamics of a sustained-
release dexamethasone (DEX) intravitreal implant (Ozurdex; Allergan, Inc.). Methods.: Thirty …

Intravitreal injection of biodegradable nanoparticles (NP) holds promise for gene therapy
and drug delivery to the back of the eye. In some cases, including gene therapy, NP need to …

Effective drug delivery to the retina still remains a challenge due to ocular elimination
mechanisms and complex barriers that selectively limit the entry of drugs into the eye. To …

Controlled drug delivery to eye is one of the most challenging fields of pharmaceutical
research. Low drugcontact time and poor ocular bioavailability due to drainage of solution …

Efficient drug delivery to the posterior segment of the eye is a challenging task for the
formulation scientist. Current treatment of chronic back-of-the-eye conditions requires …

Purpose.: To evaluate dexamethasone pharmacokinetics after implantation of a sustained-
release dexamethasone (DEX) intravitreal implant in nonvitrectomized and vitrectomized …

The advent of nanotechnology promises to drastically accelerate progress toward
nanomedicine. Nanoscale particles in the size range of cellular and molecular structures …

Smart nano-micro platforms have been extensively applied for diverse biomedical
applications, mostly focusing on cancer therapy. In comparison with conventional …