The neurons of the central nervous system (CNS) require precise control of their bathing
microenvironment for optimal function, and an important element in this control is the blood …

Neuroimaging with positron emission tomography (PET) is the most powerful tool for
understanding pharmacology, neurochemistry, and pathology in the living human brain. This …

An accurate means of predicting blood–brain barrier (BBB) penetration and blood–brain
partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical …

The aim of this study was to investigate the ability of a third-generation (G3) polyamidoamine
(PAMAM) dendrimer-based carrier to enhance the permeability of paclitaxel (pac) and to …

Despite enormous efforts, achieving a safe and efficacious concentration profile in the brain
remains one of the big challenges in central nervous system (CNS) drug discovery and …

Opioid receptors are expressed on peripheral sensory nerve endings, cutaneous cells, and
immune cells; and local application of opioids is used for the treatment of inflammatory pain …

One of the major challenges in the development of central nervous system (CNS)-targeted
drugs is predicting CNS exposure in human from preclinical data. In this study, we present a …

Several in vivo techniques have been developed to study and measure the uptake of CNS
compounds into the brain. With these techniques, various parameters can be determined …

The blood–brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels
and forms the critical interface regulating molecular flux between blood and brain. It …

Highlights•We provide guidelines for drug discovery campaigns for rare Hereditary spastic
paraplegia (HSP).•Alternative models beyond traditional drug discovery paradigms are …