Long non-coding RNAs (lncRNAs) represent a significant population of the human
transcriptome. Many lncRNAs exhibit cell-and/or tissue/tumor-specific expression, making …

Cancer represents a group of heterogeneous diseases characterized by uncontrolled
growth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a …

Antisense oligonucleotides (ASOs) are promising tools for gene silencing and have been
exploited as therapeutics for human disease. However, delivery of therapeutic ASOs to …

Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a
wide range of biomedical applications, but there are many challenges facing its therapeutic …

MicroRNAs (miRs) play an important role in regulating gene expression. Limited by their
instabilities, miR therapeutics require delivery vehicles. Tetrahedral framework nucleic acids …

The ability to artificially control transcription is essential both to the study of gene function
and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA …

Metal nanoparticles (NPs) may have the potential to overcome problems related to
conventional chemotherapy. Metal NPs reported to play a beneficial and powerful role in …

Short hairpin RNA (shRNA) technology enables stable and regulated gene repression. For
establishing experimentally versatile RNAi tools and minimizing toxicities, synthetic shRNAs …

Small interfering RNAs (siRNA) have recently emerged as a new class of therapeutics with a
great potential to revolutionize the treatment of cancer and other diseases. A specifically …

Inherent difficulties with blocking many desirable targets using conventional approaches
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach …