Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

Photochemistry has emerged as a transformative force in organic chemistry, significantly
expanding the chemical space accessible for medicinal chemistry. Light-induced reactions …

Synthesis of bicyclic scaffolds has attracted tremendous attention because they are playing
an important role as saturated bioisosteres of benzenoids in modern drug discovery. Here …

Abstract Bicyclo [2.1. 1] hexanes (BCHs) are becoming ever more important in drug design
and development as bridged scaffolds that provide underexplored chemical space, but are …

Aryl-substituted bicyclo [1.1. 1] pentane (BCP-aryl) derivatives represent the most important
bioisosteres of biaryl scaffolds and widely exist in numerous complex pharmaceutical …

Herein, we have synthesized multifunctionalized 2‐oxa‐3‐azabicyclo [3.1. 1] heptanes,
which are considered potential bioisosteres for meta‐substituted arenes, through Eu (OTf) 3 …

Synthesis of bicyclic scaffolds has emerged as an important research topic in modern drug
development because they can serve as saturated bioisosters to enhance the …

Azabicyclo [2.1. 1] hexanes (aza-BCHs) and bicyclo [1.1. 1] pentanes (BCPs) have emerged
as attractive classes of sp 3-rich cores for replacing flat, aromatic groups with metabolically …

Synthesis of bicyclo [1.1. 1] pentane (BCP) heteroaryls continues to be a part of the most
important tasks in organic synthesis because they are a significant class of bioisosteres with …

In pursuit of potent pharmaceutical candidates and to further improve their chemical traits,
small ring systems can serve as a potential starting point. Small ring units have the …