D-amino acids and D-amino acid-containing peptides: potential disease biomarkers and therapeutic targets?

M Abdulbagi, L Wang, O Siddig, B Di, B Li - Biomolecules, 2021 - mdpi.com
In nature, amino acids are found in two forms, L and D enantiomers, except for glycine which
does not have a chiral center. The change of one form to the other will lead to a change in …

[HTML][HTML] Insights of ion mobility spectrometry and its application on food safety and authenticity: A review

E Te Brinke, A Arrizabalaga-Larrañaga… - Analytica chimica …, 2022 - Elsevier
Ion mobility spectrometry (IMS) is gaining importance in the field of food safety and
authenticity in recent years due to its main potential to overcome the challenges that arise …

Quantitative shotgun proteome analysis by direct infusion

JG Meyer, NM Niemi, DJ Pagliarini, JJ Coon - Nature methods, 2020 - nature.com
Liquid chromatography–mass spectrometry (LC–MS) delivers sensitive peptide analysis for
proteomics but requires extensive analysis time, reducing throughput. Here, we demonstrate …

General method to obtain collision cross-section values in multipass high-resolution cyclic ion mobility separations

SC Habibi, G Nagy - Analytical chemistry, 2023 - ACS Publications
In recent years, ion mobility spectrometry-mass spectrometry (IMS-MS) has advanced the
field of omics-based research, especially with the development of high-resolution platforms; …

Recent advances in high‐resolution traveling wave‐based ion mobility separations coupled to mass spectrometry

CN Naylor, G Nagy - Mass Spectrometry Reviews, 2024 - Wiley Online Library
Recently, ion mobility spectrometry‐mass spectrometry (IMS‐MS) has become more readily
incorporated into various omics‐based workflows. These growing applications are due to …

Separation and Characterization of Synthetic Cannabinoid Metabolite Isomers Using SLIM High-Resolution Ion Mobility-Tandem Mass Spectrometry (HRIM-MS/MS)

R Aderorho, SW Lucas… - Journal of the American …, 2024 - ACS Publications
Synthetic cannabinoids, a subclass of new psychoactive substances (NPS), are laboratory-
made substances that are chemically similar to those found naturally in the cannabis plant …

Enhanced top-down protein characterization with electron capture dissociation and cyclic ion mobility spectrometry

JB Shaw, DA Cooper-Shepherd, D Hewitt… - Analytical …, 2022 - ACS Publications
Tandem mass spectrometry of denatured, multiply charged high mass protein precursor ions
yield extremely dense spectra with hundreds of broad and overlap** product ion isotopic …

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer's disease

S Mukherjee, KA Perez, LC Lago, S Klatt… - Brain …, 2021 - academic.oup.com
Plaques that characterize Alzheimer's disease accumulate over 20 years as a result of
decreased clearance of amyloid-β peptides. Such long-lived peptides are subjected to …

High-resolution ion-mobility-enabled peptide map** for high-throughput critical quality attribute monitoring

JR Arndt, KL Wormwood Moser… - Journal of the …, 2021 - ACS Publications
Characterization and monitoring of post-translational modifications (PTMs) by peptide
map** is a ubiquitous assay in biopharmaceutical characterization. Often, this assay is …

Differential Ion Mobility Separations of d/l Peptide Epimers

F Berthias, MA Baird, AA Shvartsburg - Analytical Chemistry, 2021 - ACS Publications
Life was originally assumed to utilize the l-amino acids only. Since 1980s, the d-amino acid-
containing peptides (DAACPs) were detected in animals, often at extremely low levels with …