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D-amino acids and D-amino acid-containing peptides: potential disease biomarkers and therapeutic targets?
In nature, amino acids are found in two forms, L and D enantiomers, except for glycine which
does not have a chiral center. The change of one form to the other will lead to a change in …
does not have a chiral center. The change of one form to the other will lead to a change in …
[HTML][HTML] Insights of ion mobility spectrometry and its application on food safety and authenticity: A review
Ion mobility spectrometry (IMS) is gaining importance in the field of food safety and
authenticity in recent years due to its main potential to overcome the challenges that arise …
authenticity in recent years due to its main potential to overcome the challenges that arise …
Quantitative shotgun proteome analysis by direct infusion
Liquid chromatography–mass spectrometry (LC–MS) delivers sensitive peptide analysis for
proteomics but requires extensive analysis time, reducing throughput. Here, we demonstrate …
proteomics but requires extensive analysis time, reducing throughput. Here, we demonstrate …
General method to obtain collision cross-section values in multipass high-resolution cyclic ion mobility separations
In recent years, ion mobility spectrometry-mass spectrometry (IMS-MS) has advanced the
field of omics-based research, especially with the development of high-resolution platforms; …
field of omics-based research, especially with the development of high-resolution platforms; …
Recent advances in high‐resolution traveling wave‐based ion mobility separations coupled to mass spectrometry
Recently, ion mobility spectrometry‐mass spectrometry (IMS‐MS) has become more readily
incorporated into various omics‐based workflows. These growing applications are due to …
incorporated into various omics‐based workflows. These growing applications are due to …
Separation and Characterization of Synthetic Cannabinoid Metabolite Isomers Using SLIM High-Resolution Ion Mobility-Tandem Mass Spectrometry (HRIM-MS/MS)
R Aderorho, SW Lucas… - Journal of the American …, 2024 - ACS Publications
Synthetic cannabinoids, a subclass of new psychoactive substances (NPS), are laboratory-
made substances that are chemically similar to those found naturally in the cannabis plant …
made substances that are chemically similar to those found naturally in the cannabis plant …
Enhanced top-down protein characterization with electron capture dissociation and cyclic ion mobility spectrometry
Tandem mass spectrometry of denatured, multiply charged high mass protein precursor ions
yield extremely dense spectra with hundreds of broad and overlap** product ion isotopic …
yield extremely dense spectra with hundreds of broad and overlap** product ion isotopic …
Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer's disease
Plaques that characterize Alzheimer's disease accumulate over 20 years as a result of
decreased clearance of amyloid-β peptides. Such long-lived peptides are subjected to …
decreased clearance of amyloid-β peptides. Such long-lived peptides are subjected to …
High-resolution ion-mobility-enabled peptide map** for high-throughput critical quality attribute monitoring
JR Arndt, KL Wormwood Moser… - Journal of the …, 2021 - ACS Publications
Characterization and monitoring of post-translational modifications (PTMs) by peptide
map** is a ubiquitous assay in biopharmaceutical characterization. Often, this assay is …
map** is a ubiquitous assay in biopharmaceutical characterization. Often, this assay is …
Differential Ion Mobility Separations of d/l Peptide Epimers
Life was originally assumed to utilize the l-amino acids only. Since 1980s, the d-amino acid-
containing peptides (DAACPs) were detected in animals, often at extremely low levels with …
containing peptides (DAACPs) were detected in animals, often at extremely low levels with …