Background and purpose Myasthenia gravis (MG) is an autoimmune disease with muscular
weakness as the only symptom, and often with immunosuppressive treatment. All these …

SARS-coronavirus 2 is the causal agent of the COVID-19 outbreak. SARS-Cov-2 entry into a
cell is dependent upon binding of the viral spike (S) protein to cellular receptor and on …

Introduction Many loci segregate alleles classified as “genetic diseases” due to their
deleterious effects on health. However, some disease alleles have been reported to show …

Hardy-Weinberg Equilibrium (HWE) is used to estimate the number of homozygous and
heterozygous variant carriers based on its allele frequency in populations that are not …

This study, conducted in the Republic of North Ossetia-Alania (RNOA), aimed to explore the
genetic landscape of hyperphenylalaninemia (HPA) and phenylketonuria (PKU) in the …

Human beings are sometime expose to the same to predisposing factors of a given
infectious disease, but the outcome in terms of disease manifestation differs greatly. This …

Background Diagnostic reasoning requires clinicians to think through complex uncertainties.
We tested the possibility of a bias toward an available single diagnosis in uncertain cases …

Main Text: Allergic and autoimmune diseases such as asthma, psoriasis, rheumatoid
arthritis and inflammatory bowel disease vary in prevalence within human populations1, 2 …

Systemic pools of ATP are elevated in individuals homozygous for cystic fibrosis (CF) as
evidenced by elevated blood and plasma ATP levels. This elevated ATP level seems to …

Water, essential for the biology of living organisms, is also important for agriculture, for the
organization of social life and for culture. In this review we discuss the interrelationship …