Tau protein is involved in various cellular processes, including having a canonical role in
binding and stabilization of microtubules in neurons. Tauopathies are neurodegenerative …

For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

Recent discoveries of rare variants of human APOE may shed light on novel therapeutic
strategies for Alzheimer's disease (AD). Here, we highlight the newly identified protective …

Alzheimer's disease (AD) is a complex, progressive primary neurodegenerative disease.
Since pivotal genetic studies in 1993, the ε4 allele of the apolipoprotein E gene (APOE ε4) …

INTRODUCTION The apolipoprotein E gene (APOE) is an established central player in the
pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse …

Human apolipoprotein E (ApoE) was first identified as a polymorphic gene in the 1970s;
however, the genetic association of ApoE genotypes with late-onset sporadic Alzheimer's …

Synaptic dysfunction is a critical pathological feature in the early phase of Alzheimer's
disease (AD) that precedes typical hallmarks of AD, including beta-amyloid (Aβ) plaques …

Alzheimer's disease is characterized by progressive cognitive decline, and behavioural and
psychological symptoms of dementia are common. The APOE ε4 allele, a genetic risk factor …