The involvement of the oxidative stress status in cancer pathology: a double view on the role of the antioxidants
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …
are known by their “double‐sided” nature in biological systems. The beneficial effects of …
Can NF-κB be considered a valid drug target in neoplastic diseases? Our point of view
M Labbozzetta, M Notarbartolo, P Poma - International journal of …, 2020 - mdpi.com
Multidrug resistance (MDR), of the innate and acquired types, is one of major problems in
treating tumor diseases with a good chance of success. In this review, we examine the key …
treating tumor diseases with a good chance of success. In this review, we examine the key …
Syntenin-1-mediated small extracellular vesicles promotes cell growth, migration, and angiogenesis by increasing onco-miRNAs secretion in lung cancer cells
Small extracellular vesicles (sEVs) play a pivotal role in tumor progression by mediating
intercellular communication in the tumor microenvironment (TME). Syntenin-1 induces …
intercellular communication in the tumor microenvironment (TME). Syntenin-1 induces …
Antimetastatic effects of curcumin in oral and gastrointestinal cancers
Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that
can cause the high rate mortality in the world. Metastasis is a significant destructive feature …
can cause the high rate mortality in the world. Metastasis is a significant destructive feature …
Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β
Melanoma differentiation associated gene-9 (MDA-9), Syntenin-1, or syndecan binding
protein is a differentially regulated prometastatic gene with elevated expression in advanced …
protein is a differentially regulated prometastatic gene with elevated expression in advanced …
The Multifunctional Protein Syntenin-1: Regulator of Exosome Biogenesis, Cellular Function, and Tumor Progression
KM Lee, EC Seo, JH Lee, HJ Kim… - International journal of …, 2023 - mdpi.com
Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1
(PDZ) domains, participating in multiple signaling pathways and modulating cellular …
(PDZ) domains, participating in multiple signaling pathways and modulating cellular …
MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein
Tumor metastasis comprises a series of coordinated events that culminate in dissemination
of cancer cells to distant sites within the body representing the greatest challenge impeding …
of cancer cells to distant sites within the body representing the greatest challenge impeding …
Melanoma differentiation associated gene‐9/syndecan binding protein promotes hepatocellular carcinoma
Melanoma differentiation associated gene‐9/syndecan binding... : Hepatology Melanoma
differentiation associated gene‐9/syndecan binding protein promotes hepatocellular carcinoma …
differentiation associated gene‐9/syndecan binding protein promotes hepatocellular carcinoma …
Single-cell RNA-seq reveals the transcriptional program underlying tumor progression and metastasis in neuroblastoma
Z Nian, D Wang, H Wang, W Liu, Z Ma, J Yan, Y Cao… - Frontiers of …, 2024 - Springer
Neuroblastoma (NB) is one of the most common childhood malignancies. Sixty percent of
patients present with widely disseminated clinical signs at diagnosis and exhibit poor …
patients present with widely disseminated clinical signs at diagnosis and exhibit poor …
Emerging therapeutic targets for neuroblastoma
N Aravindan, T Herman, S Aravindan - Expert opinion on …, 2020 - Taylor & Francis
Introduction Neuroblastoma (NB) is the prime cancer of infancy, and accounts for 9% of
pediatric cancer deaths. While children diagnosed with clinically stable NB experience a …
pediatric cancer deaths. While children diagnosed with clinically stable NB experience a …