Tumour predisposition and cancer syndromes as models to study gene–environment interactions

M Carbone, ST Arron, B Beutler, A Bononi… - Nature Reviews …, 2020 - nature.com
Cell division and organismal development are exquisitely orchestrated and regulated
processes. The dysregulation of the molecular mechanisms underlying these processes …

Mitochondria and oxygen homeostasis

MP Mori, R Penjweini, JR Knutson, P Wang… - The FEBS …, 2022 - Wiley Online Library
Molecular oxygen possesses a dual nature due to its highly reactive free radical property: it
is capable of oxidizing metabolic substrates to generate cellular energy, but can also serve …

Explainable artificial intelligence (XAI) for exploring spatial variability of lung and bronchus cancer (LBC) mortality rates in the contiguous USA

ZU Ahmed, K Sun, M Shelly, L Mu - Scientific reports, 2021 - nature.com
Abstract Machine learning (ML) has demonstrated promise in predicting mortality; however,
understanding spatial variation in risk factor contributions to mortality rate requires …

[HTML][HTML] Histologic lung cancer incidence rates and trends vary by race/ethnicity and residential county

KA Houston, KA Mitchell, J King, A White… - Journal of Thoracic …, 2018 - Elsevier
Introduction Lung cancer incidence is higher among non-Hispanic (NH) blacks than among
the NH white and Hispanic populations in the United States. However, national cancer …

Morphological and molecular-biological features of glioblastoma progression in tolerant and susceptible to hypoxia Wistar rats

DS Dzhalilova, NA Zolotova, VA Mkhitarov… - Scientific reports, 2023 - nature.com
Hypoxia is a major pathogenetic factor in many cancers. Individual resistance to suboptimal
oxygen availability is subject to broad variation and its possible role in tumorigenesis …

HIF-dependent mechanisms of relationship between hypoxia tolerance and tumor development

DS Dzhalilova, OV Makarova - Biochemistry (Moscow), 2021 - Springer
Oxygen deficiency is one of the key pathogenetic factors determining development and
severity of many diseases, including inflammatory, infectious diseases, and cancer. Lack of …

Revisiting the COVID-19 fatality rate and altitude association through a comprehensive analysis

C Bridgman, J Gerken, J Vincent, AE Brooks… - Scientific Reports, 2022 - nature.com
The emergence of COVID-19 virus has led to a pandemic with staggering morbidity and
mortality. There is evidence showing that pre-existing conditions and environmental factors …

Influence of the atmospheric environment on spatial variation of lung cancer incidence in China

H Yu, Y Wang, X Yue, H Zhang - Plos one, 2024 - journals.plos.org
Conducting this research contributes to a deeper understanding of the correlation between
atmospheric environmental quality and lung cancer incidence, and provides the scientific …

High altitude and cancer mortality

M Thiersch, ER Swenson - High altitude medicine & biology, 2018 - liebertpub.com
Abstract Thiersch, Markus, and Erik R. Swenson. High altitude and cancer mortality. High Alt
Med Biol 19: 116–123, 2018.—Humans living at high altitude (HA) are exposed to chronic …

[HTML][HTML] The oxygen transport triad in high-altitude pulmonary edema: a perspective from the high Andes

G Zubieta-Calleja, N Zubieta-DeUrioste - International Journal of …, 2021 - mdpi.com
Acute high-altitude illnesses are of great concern for physicians and people traveling to high
altitude. Our recent article “Acute Mountain Sickness, High-Altitude Pulmonary Edema and …