▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are
abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent …

Abstract Avila, Jesús, José J. Lucas, Mar Pérez, and Félix Hernández. Role of Tau Protein in
Both Physiological and Pathological Conditions. Physiol Rev 84: 361–384, 2004; …

As a principal neuronal microtubule-associated protein, tau has been recognized to play
major roles in promoting microtubule assembly and stabilizing the microtubules and to …

Tau is a multifunctional protein that was originally identified as a microtubule‐associated
protein. In patients diagnosed with frontotemporal dementia and parkinsonism linked to …

Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and
cognition, definitively diagnosed only at autopsy. Here, we conduct a genome-wide …

Objective An inversion polymorphism of approximately 900kb on chromosome 17q21, which
includes the microtubule‐associated protein tau (MAPT) gene defines two haplotype clades …

Pathological tau protein inclusions have long been recognized to define the diverse range of
neurodegenerative disorders called the tauopathies, which include Alzheimer's disease …

Tau is not only a basic component of neurofibrillary degeneration, but is also an aetiological
factor, as demonstrated by mutations on the tau gene responsible for frontotemporal …

Abundant cytoplasmic inclusions consisting of aggregated hyperphosphorylated protein tau
are a characteristic pathological observation in several neurodegenerative disorders such …

Background Frontotemporal dementia (FTD) is an important cause of neurodegenerative
dementia, particularly in younger patients. TAUhas been identified as the gene responsible …