Replication fork collision with a DNA nick can generate a one-ended break, fostering
genomic instability. The opposing fork's collision with the nick could form a second DNA end …

In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that
limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on …

Transcription and splicing are intrinsically coupled. Alternative splicing of internal exons can
fine-tune gene expression through a recently described phenomenon called exon-mediated …

Background Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a
high incidence of distant metastases and lacks targeted therapeutic options. Here we …

Eukaryotic gene regulation relies on the binding of sequence-specific transcription factors
(TFs). TFs bind chromatin transiently yet occupy their target sites by forming high-local …

Abstract Background G-quadruplex DNA (G4) is a non-canonical structure forming in
guanine-rich regions, which play a vital role in cancer biology and are now being …

Metabolic reprogramming is considered as a hallmark of cancer and is clinically exploited as
a novel target for therapy. The E2F transcription factor-1 (E2F1) regulates various cellular …

Hyperpigmented dermatoses are characterized by increased skin pigmentation caused by
genetic, environmental factors and inflammation, which lasts a long time and is difficult to …

Amelogenesis, or enamel development, is a highly regulated process that leads to the
formation of tooth enamel, which is critical for protecting teeth from decay and wear …

G-quadruplex DNA (G4) is a non-canonical structure forming in guanine-rich regions, which
play a vital role in cancer biology and are now being acknowledged in both nuclear and …