It is generally regarded that the progression of an infection within host macrophages is the
consequence of a failed immune response. However, recent appreciation of macrophage …

Emerging and re-emerging bacterial infections are a serious threat to human and animal
health. Extracellular bacteria are free-living, while facultative intracellular bacteria replicate …

Under homeostatic conditions, macrophages derived from different ontogenies coexist in
many tissues. In these situations, it is unclear the extent to which macrophage origin versus …

Dissecting the in vivo host-pathogen interplay is crucial to understanding the molecular
mechanisms governing control or progression of intracellular infections. In this work, we …

Virulence is described as an ability of an organism to infect the host and cause a disease.
Virulence factors are the molecules that assist the bacterium colonize the host at the cellular …

Neutrophils represent the main infected cell population in the lungs of active tuberculosis
patients. Efficient removal of infected and dying neutrophils is required to protect the …

How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate
survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously …

Recent data indicate that the nutrients available to Mycobacterium tuberculosis (Mtb) inside
its host cell are restricted in their diversity. Fatty acids and cholesterol appear more favored; …

Deciphering physiological changes that mediate transition of Mycobacterium tuberculosis
between replicating and nonreplicating states is essential to understanding how the …

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to
support growth in macrophages. By conducting an extensive, unbiased chemical screen to …