In order to cure diseases efficiently with minimal side effects in sophisticated medicine,
eminent drugs must be selectively delivered to diseased parts and allow to work only there …

As chiral molecules, naturally occurring d‐oligonucleotides have enantiomers, l‐DNA and l‐
RNA, which are comprised of l‐(deoxy) ribose sugars. These mirror‐image oligonucleotides …

DNA nanotechnology has recently provided a novel approach for develo** safe,
biocompatible, biodegradable, non-immunogenic, and non-toxic drug delivery systems …

DNA and RNA nanostructures are being investigated as therapeutics, vaccines, and drug
delivery systems. These nanostructures can be functionalized with guests ranging from …

Chemically modified nucleotides are central to the development of biostable research tools
and oligonucleotide therapeutics. In this context, L-oligonucleotides, the synthetic …

DNA amplification circuits that rely on thermodynamically-driven hybridization events
triggered by a target nucleic acid are becoming increasingly utilized due to their relative …

Naturally occurring DNA, RNA, and proteins predominantly exist in only one enantiomeric
form (homochirality). Advances in biotechnology and chemical synthesis allow the …

Due to their intrinsic nuclease resistance, mirror image L-oligonucleotides are being
increasingly employed in the development of biomedical research tools and therapeutics …

Nucleic acids are often covalently modified with fluorescent reporter molecules to create a
hybridization state-dependent optical signal. Designing such a nucleic acid reporter involves …

The intrinsic L-DNA binding properties of a natural DNA polymerase was discovered. The
binding affinity of Dpo4 polymerase for L-DNA was comparable to that for D-DNA. The …