Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy

Y Zong, Y Lin, T Wei, Q Cheng - Advanced Materials, 2023 - Wiley Online Library
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

Immune cell Membrane‐Coated biomimetic nanoparticles for targeted cancer therapy

F Oroojalian, M Beygi, B Baradaran, A Mokhtarzadeh… - Small, 2021 - Wiley Online Library
Nanotechnology has provided great opportunities for managing neoplastic conditions at
various levels, from preventive and diagnostic to therapeutic fields. However, when it comes …

Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response

J Chen, Z Ye, C Huang, M Qiu… - Proceedings of the …, 2022 - National Acad Sciences
The targeted delivery of messenger RNA (mRNA) to desired organs remains a great
challenge for in vivo applications of mRNA technology. For mRNA vaccines, the targeted …

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

EH Pilkington, EJA Suys, NL Trevaskis, AK Wheatley… - Acta biomaterialia, 2021 - Elsevier
Vaccination represents the best line of defense against infectious diseases and is crucial in
curtailing pandemic spread of emerging pathogens to which a population has limited …

Opportunities and challenges in the delivery of mRNA-based vaccines

A Wadhwa, A Aljabbari, A Lokras, C Foged, A Thakur - Pharmaceutics, 2020 - mdpi.com
In the past few years, there has been increasing focus on the use of messenger RNA
(mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based …

Cancer nanotechnology: current status and perspectives

JA Kemp, YJ Kwon - Nano convergence, 2021 - Springer
Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

Natural killer cells: a promising immunotherapy for cancer

J Chu, F Gao, M Yan, S Zhao, Z Yan, B Shi… - Journal of translational …, 2022 - Springer
As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Progress and prospects on vaccine development against SARS-CoV-2

J Zhang, H Zeng, J Gu, H Li, L Zheng, Q Zou - Vaccines, 2020 - mdpi.com
In December 2019, the outbreak of pneumonia caused by a novel coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a serious pandemic in China …

Current developments and challenges of mRNA vaccines

J Chen, J Chen, Q Xu - Annual Review of Biomedical …, 2022 - annualreviews.org
mRNA vaccines have brought about a great revolution in the vaccine fields owing to their
simplicity and adaptability in antigen design, potential to induce both humoral and cell …

[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy

Q **ao, X Li, Y Li, Z Wu, C Xu, Z Chen, W He - Acta Pharmaceutica Sinica B, 2021 - Elsevier
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …