In the last years, mortality from breast cancer has declined in western countries as a
consequence of a more widespread screening resulting in earlier detection, as well as an …

HPA axis genes implicated in glucocorticoid regulation play an important role in regulating
the physiological impact of social and environmental stress, and have become a focal point …

Epigenetic changes are defined as inherited modifications that are not present in DNA
sequence. Gene expression is regulated at various levels and not only in response to DNA …

'Epigenetics' is defined as the inheritable changes in gene expression with no alterations in
DNA sequences. Epigenetics is a rapidly expanding field, and the study of epigenetic …

Background DNA hypermethylation events and other epimutations occur in many
neoplasms, producing gene expression changes that contribute to neoplastic …

Any alteration at the genetic or epigenetic level, may result in multiplex of diseases including
tumorigenesis which ultimately results in the cancer development. Restoration of the normal …

Background Aberrant DNA methylation patterns might be used as a biomarker for diagnosis
and management of cancer patients. Methods and Findings To achieve a gene panel for …

Background The E-cadherin gene (CDH1) maps, at chromosome 16q22. 1, a region often
associated with loss of heterozygosity (LOH) in human breast cancer. LOH at this site is …

The active acquisition of epigenetic changes is a poorly understood but important process in
development, differentiation, and disease. Our work has shown that repression of the …

Epigenetic association studies have demonstrated differential promoter methylation in the
core circadian genes in breast cancer cases relative to cancer-free controls. The current pilot …