Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

Biological energy conversion is driven by efficient enzymes that capture, store and transfer
protons and electrons across large distances. Recent advances in structural biology have …

Respiratory complex I, a key enzyme in mammalian metabolism, captures the energy
released by reduction of ubiquinone by NADH to drive protons across the inner …

INTRODUCTION Complex I is the first and, with 45 subunits and a total mass of~ 1 MDa, the
most elaborate of the mitochondrial electron transfer chain enzymes. Complex I converts …

Complex I is a redox-driven proton pump that drives electron transport chains and powers
oxidative phosphorylation across all domains of life. Yet, despite recently resolved structures …

Complex I (NADH: ubiquinone oxidoreductase) uses the reducing potential of NADH to drive
protons across the energy-transducing inner membrane and power oxidative …

Mitochondrial complex I powers ATP synthesis by oxidative phosphorylation, exploiting the
energy from ubiquinone reduction by NADH to drive protons across the energy-transducing …

Complex I is the first and the largest enzyme of respiratory chains in bacteria and
mitochondria. The mechanism which couples spatially separated transfer of electrons to …

Highlights•Respiratory complex I (NADH: ubiquinone oxidoreductase) is a redox-driven
proton pump.•Bacterial MBH and plastid NDH are members of the complex I superfamily.• …

Conspectus Biological energy conversion is catalyzed by membrane-bound proteins that
transduce chemical or light energy into energy forms that power endergonic processes in …