Many species, including humans, host communities of symbiotic microbes. There is a vast
literature on the ways these microbiomes affect hosts, but here we argue for an increased …

Bacteria‐induced epidemics and infectious diseases are seriously threatening the health of
people around the world. In addition, antibiotic therapy has been inducing increasingly more …

Dimeric IgA secreted across mucous membranes in response to nonpathogenic taxa of the
microbiota accounts for most antibody production in mammals. Diverse binding specificities …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Urinary tract infections (UTIs) are among the most common bacterial infections seen in
clinical practice. The ascent of UTI-causing pathogens to the kidneys results in …

Lower urinary tract infection (UTI) is common but only rarely complicated by pyelonephritis.
However, the mechanisms preventing extension to the kidney are unclear. Here, we …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein
secreted bidirectionally into urine and into the circulation, and it is the most abundant protein …

Abstract Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against
gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin …

Urinary tract infection (UTI) is among the most common infections in clinical practice. In
some cases, if left untreated, it can lead to pyelonephritis and urosepsis. In other cases, UTI …