Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review
The leading cause of several degenerative diseases such as atherosclerosis, cancer, aging,
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
Oral delivery of anticancer drugs: challenges and opportunities
The present report focuses on the various aspects of oral delivery of anticancer drugs. The
significance of oral delivery in cancer therapeutics has been highlighted which principally …
significance of oral delivery in cancer therapeutics has been highlighted which principally …
Synovial fibroblasts: key players in rheumatoid arthritis
LC Huber, O Distler, I Tarner, RE Gay, S Gay… - Rheumatology, 2006 - academic.oup.com
Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily
affects the joints and ultimately leads to their destruction. The involvement of immune cells is …
affects the joints and ultimately leads to their destruction. The involvement of immune cells is …
Mechanism-based profiling of enzyme families
Genome sequencing projects have ushered biological research into a new age where
scientists are confronted with the daunting undertaking of assigning functions to the full …
scientists are confronted with the daunting undertaking of assigning functions to the full …
Metastasis review: from bench to bedside
Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …
associated diseases. One major aspect of cancer is when cells attack adjacent components …
Advances in therapeutic targeting of cancer stem cells within the tumor microenvironment: an updated review
Despite great strides being achieved in improving cancer patients' outcomes through better
therapies and combinatorial treatment, several hurdles still remain due to therapy …
therapies and combinatorial treatment, several hurdles still remain due to therapy …
Profiling the structural determinants of pyrrolidine derivative as gelatinases (MMP-2 and MMP-9) inhibitors using in silico approaches
Quantitative structure activity relationship (QSAR) studies on pyrrolidine derivatives have
been established using CoMFA, CoMSIA, and Hologram QSAR analysis to estimate the …
been established using CoMFA, CoMSIA, and Hologram QSAR analysis to estimate the …
The role of endogenous and exogenous enzymes in chronic wounds: a focus on the implications of aberrant levels of both host and bacterial proteases in wound …
SM McCarty, CA Cochrane, PD Clegg… - Wound Repair and …, 2012 - Wiley Online Library
Cutaneous wound healing is orchestrated by a number of physiological pathways that
ultimately lead to reformation of skin integrity and the production of functional scar tissue …
ultimately lead to reformation of skin integrity and the production of functional scar tissue …
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
J Brábek, CT Mierke, D Rösel, P Veselý… - Cell communication and …, 2010 - Springer
During malignant neoplastic progression the cells undergo genetic and epigenetic cancer-
specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the …
specific alterations that finally lead to a loss of tissue homeostasis and restructuring of the …
Recent advances in MMP inhibitor design
JF Fisher, S Mobashery - Cancer and Metastasis Reviews, 2006 - Springer
The search for an MMP inhibitor with anticancer efficacy is a nearly three-decade endeavor.
This inhibitor is yet to be found. The reasons for this failure include shortcomings in the …
This inhibitor is yet to be found. The reasons for this failure include shortcomings in the …