Interferon gene therapy with nadofaragene firadenovec for bladder cancer: from bench to approval
Bladder cancer is a prevalent malignancy with limited therapeutic options, particularly for
patients who are unresponsive to Bacillus Calmette-Guérin (BCG). The approval of …
patients who are unresponsive to Bacillus Calmette-Guérin (BCG). The approval of …
The current status of gene therapy in bladder cancer
Introduction Gene therapy aims to alter the biological properties of cells through the
therapeutic delivery of nucleotides to treat a disease. Although originally developed to treat …
therapeutic delivery of nucleotides to treat a disease. Although originally developed to treat …
Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery
Bladder cancer poses considerable therapeutic difficulties owing to its elevated rates of
recurrence and the constraints of existing treatment methods. This study examines the …
recurrence and the constraints of existing treatment methods. This study examines the …
Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model
Introduction Nadofaragene firadenovec (Ad-IFNα/Syn3) is now approved for BCG-
unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor …
unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor …
Designing molecules: directing stem cell differentiation
K Thanaskody, FN Natashah, F Nordin… - … in Bioengineering and …, 2024 - frontiersin.org
Stem cells have been widely applied in regenerative and therapeutic medicine for their
unique regenerative properties. Although much research has shown their potential, it …
unique regenerative properties. Although much research has shown their potential, it …
Integrating gene therapy into the treatment paradigm for non-muscle invasive bladder cancer
AR Steinmetz, B Jazayeri, M Pierce… - Expert Opinion on …, 2025 - Taylor & Francis
Introduction Approximately 75% of bladder cancer cases are non-muscle invasive at
diagnosis. Drug development for non-muscle invasive bladder cancer (NMIBC) has …
diagnosis. Drug development for non-muscle invasive bladder cancer (NMIBC) has …
A efetividade da imunoterapia em diferentes tipos de câncer: um estudo ciênciometrico
AKF Frota, KARF Jobim, FCJ da Silva… - Revista Eletrônica …, 2025 - acervomais.com.br
Objetivo: Avaliar a efetividade da imunoterapia em uma ampla gama de neoplasias.
Métodos: Estudo cienciométrico utilizando as bases de dados PubMed, Scientific Electronic …
Métodos: Estudo cienciométrico utilizando as bases de dados PubMed, Scientific Electronic …
Challenges and Opportunities of Gene Therapy in Cancer
M Mittal, A Kumari, B Paul, A Varshney, A Saini… - OBM Genetics, 2024 - lidsen.com
Gene therapy involves either the direct introduction of genetic material (DNA or RNA) into
the host cell (or organ), known as in vivo gene therapy, the re-introduction of the modified …
the host cell (or organ), known as in vivo gene therapy, the re-introduction of the modified …