Interferon gene therapy with nadofaragene firadenovec for bladder cancer: from bench to approval

A Martini, C Tholomier, S Mokkapati… - Frontiers in …, 2023 - frontiersin.org
Bladder cancer is a prevalent malignancy with limited therapeutic options, particularly for
patients who are unresponsive to Bacillus Calmette-Guérin (BCG). The approval of …

The current status of gene therapy in bladder cancer

C Tholomier, A Martini, S Mokkapati… - Expert review of …, 2023 - Taylor & Francis
Introduction Gene therapy aims to alter the biological properties of cells through the
therapeutic delivery of nucleotides to treat a disease. Although originally developed to treat …

Cell-targeting Nanomedicine for Bladder Cancer: A Cellular Bioengineering Approach for Precise Drug Delivery

ZS Hosseini, S Zeinalilathori, S Fathi-karkan… - Journal of Drug Delivery …, 2024 - Elsevier
Bladder cancer poses considerable therapeutic difficulties owing to its elevated rates of
recurrence and the constraints of existing treatment methods. This study examines the …

Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model

AR Steinmetz, M Pierce, A Martini, C Tholomier… - Frontiers in …, 2024 - frontiersin.org
Introduction Nadofaragene firadenovec (Ad-IFNα/Syn3) is now approved for BCG-
unresponsive bladder cancer (BLCA). IFNα is a pleiotropic cytokine that causes direct tumor …

Designing molecules: directing stem cell differentiation

K Thanaskody, FN Natashah, F Nordin… - … in Bioengineering and …, 2024 - frontiersin.org
Stem cells have been widely applied in regenerative and therapeutic medicine for their
unique regenerative properties. Although much research has shown their potential, it …

Integrating gene therapy into the treatment paradigm for non-muscle invasive bladder cancer

AR Steinmetz, B Jazayeri, M Pierce… - Expert Opinion on …, 2025 - Taylor & Francis
Introduction Approximately 75% of bladder cancer cases are non-muscle invasive at
diagnosis. Drug development for non-muscle invasive bladder cancer (NMIBC) has …

A efetividade da imunoterapia em diferentes tipos de câncer: um estudo ciênciometrico

AKF Frota, KARF Jobim, FCJ da Silva… - Revista Eletrônica …, 2025 - acervomais.com.br
Objetivo: Avaliar a efetividade da imunoterapia em uma ampla gama de neoplasias.
Métodos: Estudo cienciométrico utilizando as bases de dados PubMed, Scientific Electronic …

Challenges and Opportunities of Gene Therapy in Cancer

M Mittal, A Kumari, B Paul, A Varshney, A Saini… - OBM Genetics, 2024 - lidsen.com
Gene therapy involves either the direct introduction of genetic material (DNA or RNA) into
the host cell (or organ), known as in vivo gene therapy, the re-introduction of the modified …