Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Antibiotic resistance has become a global public health priority. Polymyxins, a family of
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

1 Liu YY, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance
mechanism MCR-1 in animals and human beings in China: a microbiological and molecular …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …

Background Antibiotic-resistant pathogens are challenging treatment of infections
worldwide. Urban sewage is potentially a major conduit for dissemination of antibiotic …

In this Leading article, we summarize current knowledge of the occurrence of the first and so
far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is …