Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

There has been an upsurge of interest in the adipocyte coincident with the onset of the
obesity epidemic and the realization that adipose tissue plays a major role in the regulation …

Nonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not
promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

Leptin is an adipose tissue hormone that functions as an afferent signal in a negative
feedback loop that maintains homeostatic control of adipose tissue mass. This endocrine …

Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2
diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic …

Glucagon is secreted from the pancreatic alpha cells upon hypoglycemia and stimulates
hepatic glucose production. Type 2 diabetes is associated with dysregulated glucagon …