Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
MJ Doenhoff, D Cioli, J Utzinger - Current opinion in infectious …, 2008 - journals.lww.com
Use of PZQ will increase in the foreseeable future, whether given alone or coadministered
with other anthelminthics in integrated control programmes. PZQ resistance remains a threat …
with other anthelminthics in integrated control programmes. PZQ resistance remains a threat …
Glutathione and infection
BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
demonstrated protective abilities against the detrimental effects of oxidative stress within the …
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease
The perceived and actual burden of false positives in high-throughput screening has
received considerable attention; however, few studies exist on the contributions of distinct …
received considerable attention; however, few studies exist on the contributions of distinct …
Inhibition of Schistosoma mansoni thioredoxin-glutathione reductase by auranofin: structural and kinetic aspects
Schistosomiasis is a parasitic disease affecting over 200 million people currently treated
with one drug, praziquantel. A possible drug target is the seleno-protein thioredoxin …
with one drug, praziquantel. A possible drug target is the seleno-protein thioredoxin …
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
Abstract Treatment for schistosomiasis, which is responsible for more than 280,000 deaths
annually, depends almost exclusively on praziquantel. Millions of people are treated …
annually, depends almost exclusively on praziquantel. Millions of people are treated …
Thioredoxin reductase and its inhibitors
F Saccoccia, F Angelucci, G Boumis… - Current Protein and …, 2014 - benthamdirect.com
Thioredoxin plays a crucial role in a wide number of physiological processes, which span
from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics …
from reduction of nucleotides to deoxyriboucleotides to the detoxification from xenobiotics …
Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs
MJ Doenhoff, P Hagan, D Cioli, V Southgate… - Parasitology, 2009 - cambridge.org
Treatment with praziquantel (PZQ) has become virtually the sole basis of schistosomiasis
control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of …
control in sub-Saharan Africa and elsewhere, and the drug is reviewed here in the context of …
Antischistosomal agents: state of art and perspectives
EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
Tackling assay interference associated with small molecules
L Tan, S Hirte, V Palmacci, C Stork… - Nature Reviews …, 2024 - nature.com
Biochemical and cell-based assays are essential to discovering and optimizing efficacious
and safe drugs, agrochemicals and cosmetics. However, false assay readouts stemming …
and safe drugs, agrochemicals and cosmetics. However, false assay readouts stemming …
A robotic platform for quantitative high-throughput screening
S Michael, D Auld, C Klumpp, A Jadhav… - Assay and drug …, 2008 - liebertpub.com
High-throughput screening (HTS) is increasingly being adopted in academic institutions,
where the decoupling of screening and drug development has led to unique challenges, as …
where the decoupling of screening and drug development has led to unique challenges, as …