[HTML][HTML] Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment

Y Zhao, X Zhang, X Chen… - … journal of molecular …, 2022‏ - spandidos-publications.com
Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …

[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke

Z Shen, M **ang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022‏ - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

Glutamate and GABA imbalance following traumatic brain injury

RM Guerriero, CC Giza, A Rotenberg - Current neurology and …, 2015‏ - Springer
Traumatic brain injury (TBI) leads to multiple short-and long-term changes in neuronal
circuits that ultimately conclude with an imbalance of cortical excitation and inhibition …

Protective mechanism of humanin against oxidative stress in aging-related cardiovascular diseases

H Cai, Y Liu, H Men, Y Zheng - Frontiers in Endocrinology, 2021‏ - frontiersin.org
Physiological reactive oxygen species (ROS) are important regulators of intercellular signal
transduction. Oxidative and antioxidation systems maintain a dynamic balance under …

NMDARs in cell survival and death: implications in stroke pathogenesis and treatment

Y Ge, W Chen, P Axerio-Cilies, YT Wang - Trends in molecular medicine, 2020‏ - cell.com
Stroke is a leading cause of death and disability in developed countries. N-methyl-D-
aspartate glutamate receptors (NMDARs) have important roles in stroke pathology and …

[HTML][HTML] The development of novel drug treatments for stroke patients: a review

D Frank, A Zlotnik, M Boyko… - International journal of …, 2022‏ - mdpi.com
Acute ischemic stroke is a critical condition that can result in disability and death. The
consequences of this medical condition depend on various factors, including the size of the …

[PDF][PDF] NMDA and AMPA receptors: development and status epilepticus

E Szczurowska, P Mares - Physiological research, 2013‏ - pdfs.semanticscholar.org
NMDA and AMPA Receptors: Development and Status Epilepticus Page 1
PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2013 …

What happens in TBI? A wide talk on animal models and future perspective

S Kundu, S Singh - Current neuropharmacology, 2023‏ - benthamdirect.com
Traumatic brain injury (TBI) is a global healthcare concern and a leading cause of death.
The most common causes of TBI include road accidents, sports injuries, violence in …

Ketamine and calcium signaling—A crosstalk for neuronal physiology and pathology

M Lisek, L Zylinska, T Boczek - International Journal of Molecular …, 2020‏ - mdpi.com
Ketamine is a non-competitive antagonist of NMDA (N-methyl-D-aspartate) receptor, which
has been in clinical practice for over a half century. Despite recent data suggesting its …

Brain energy metabolism in glutamate-receptor activation and excitotoxicity: role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway

P Rodriguez-Rodriguez, A Almeida… - Neurochemistry …, 2013‏ - Elsevier
Recent advances in the field of brain energy metabolism strongly suggest that glutamate
receptor-mediated neurotransmission is coupled with molecular signals that switch-on …