Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

High-precision bioengineering and synthetic biology require fine-tuning gene expression at
both transcriptional and posttranscriptional levels. Gene transcription is tightly regulated by …

Gene expression is regulated by promoters, which initiate transcription, and enhancers,
which control their temporal and spatial activity. However, the discovery that mammalian …

How transcriptional bursting relates to gene regulation is a central question that has
persisted for more than a decade. Here, we measure nascent transcriptional activity in early …

The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …

Transcription by RNA polymerase II initiates at the core promoter, which is sometimes
referred to as the “gateway to transcription.” Here, we describe the properties of the RNA …

DNA is fundamentally important for all cellular organisms due to its role as a store of
hereditary genetic information. The precise and accurate regulation of gene transcription …

Enhancers are essential drivers of cell states, yet the relationship between accessibility,
regulatory activity, and in vivo lineage commitment during embryogenesis remains poorly …

The signals that direct the initiation of transcription ultimately converge at the core promoter,
which is the gateway to transcription. Here we provide an overview of the RNA polymerase II …

Promoters play a crucial role in regulating gene transcription. However, our understanding
of how genetic variants influence alternative promoter selection is still incomplete. In this …