Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

Small molecule modulators of biological function can be discovered by the screening of
compound libraries. However, it became apparent that some human disease related targets …

In the search for new therapeutic agents for currently incurable diseases, attention has
turned to traditionally “undruggable” targets, and collections of drug-like small molecules …

Inducing neural stem cells to differentiate and replace degenerated functional neurons
represents the most promising approach for neural degenerative diseases including …

In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of
inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in …

Despite the great potential of stem cells for basic research and clinical applications,
obstacles–such as their scarce availability and difficulty in controlling their fate–need to be …

Plastic particles in the nanometer range–called nanoplastics–are environmental
contaminants with growing public health concern. As plastic particles are present in water …

Chondrogenic differentiation of mesenchymal stem cells (MSCs) is critical for successful
cartilage regeneration. Several methods have been developed to attempt to chondrogenic …

Conspectus The mammalian brain is a phenomenal piece of “organic machinery” that has
fascinated scientists and clinicians for centuries. The intricate network of tens of billions of …

Lipids are often considered membrane components whose function is to embed proteins
into cell membranes. In the last two decades, studies on brain lipids have unequivocally …