Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype
that we have previously shown to be highly efficient for discovery of genetic associations …

Genome-wide association studies (GWASs) are a research approach used to identify
genetic variants associated with common diseases, like COVID-19. The lead genetic …

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection is silent or benign
in most infected individuals, but causes hypoxemic COVID-19 pneumonia in about 10% of …

Abstract Until January 2023, Brazil recorded 37 million COVID-19 cases despite the
decrease in mortality due to mass vaccination efforts against COVID-19. The infection …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the
coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of the disease …

We analyzed the association between HLA polymorphisms and susceptibility to SARS‐CoV‐
2 infection and disease severity. Genoty** data from a total of 9373 COVID‐19‐positive …

Host genetic variability contributes to susceptibility to SARS‐CoV‐2 infection and COVID‐19
evolution and the role of HLA system has not clearly emerged, suggesting the involvement …

Despite extensive global research into genetic predisposition for severe COVID-19,
knowledge on the role of rare host genetic variants and their relation to other risk factors …

Interferons (IFNs) play a crucial role in the regulation and evolution of host–virus
interactions. Here, we conducted a genome-wide arrayed CRISPR knockout screen in the …

The contribution of human genes to the variability of disease outcomes has been shown to
be important across infectious diseases. Studies have shown mutations within specific …