Superoxide dismutases and superoxide reductases

Y Sheng, IA Abreu, DE Cabelli, MJ Maroney… - Chemical …, 2014‏ - ACS Publications
Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Thioredoxins, glutaredoxins, and peroxiredoxins—molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling

EM Hanschmann, JR Godoy, C Berndt… - Antioxidants & redox …, 2013‏ - liebertpub.com
Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae

KA Morano, CM Grant, WS Moye-Rowley - Genetics, 2012‏ - academic.oup.com
A common need for microbial cells is the ability to respond to potentially toxic environmental
insults. Here we review the progress in understanding the response of the yeast …

[HTML][HTML] Replicative and chronological aging in Saccharomyces cerevisiae

VD Longo, GS Shadel, M Kaeberlein, B Kennedy - Cell metabolism, 2012‏ - cell.com
Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Adaptive homeostasis and the free radical theory of ageing

LCD Pomatto, KJA Davies - Free Radical Biology and Medicine, 2018‏ - Elsevier
Abstract The Free Radical Theory of Ageing, was first proposed by Denham Harman in the
mid-1950's, based largely on work conducted by Rebeca Gerschman and Daniel Gilbert. At …

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

J Guevara-Aguirre, P Balasubramanian… - Science translational …, 2011‏ - science.org
Mutations in growth signaling pathways extend life span, as well as protect against age-
dependent DNA damage in yeast and decrease insulin resistance and cancer in mice. To …

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

DW Cleveland, JD Rothstein - Nature reviews neuroscience, 2001‏ - nature.com
Since its description by Charcot more than 130 years ago, the mechanism underlying the
characteristic selective degeneration and death of motor neurons in amyotrophic lateral …

Extension of chronological life span in yeast by decreased TOR pathway signaling

RW Powers, M Kaeberlein, SD Caldwell… - Genes & …, 2006‏ - genesdev.cshlp.org
Chronological life span (CLS) in Saccharomyces cerevisiae, defined as the time cells in a
stationary phase culture remain viable, has been proposed as a model for the aging of post …

Trends in oxidative aging theories

FL Muller, MS Lustgarten, Y Jang, A Richardson… - Free Radical Biology …, 2007‏ - Elsevier
The early observations on the rate-of-living theory by Max Rubner and the report by
Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the …

Oxidative stress responses of the yeast Saccharomyces cerevisiae

DJ Jamieson - Yeast, 1998‏ - Wiley Online Library
All aerobically growing organisms suffer exposure to oxidative stress, caused by partially
reduced forms of molecular oxygen, known as reactive oxygen species (ROS). These are …