Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms

A Yiangou, SP Mollan, AJ Sinclair - Nature Reviews Neurology, 2023 - nature.com
The understanding of idiopathic intracranial hypertension (IIH) has evolved over the past few
years. Previously, IIH was considered a disease exclusively affecting the neuro-ophthalmic …

Idiopathic intracranial hypertension: pathophysiology, diagnosis and management

MTM Wang, MT Bhatti, HV Danesh-Meyer - Journal of Clinical …, 2022 - Elsevier
Idiopathic intracranial hypertension (IIH) is characterized by increased intracranial pressure,
manifested by papilledema and radiological findings, in the absence of an identifiable …

[HTML][HTML] Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension

CSJ Westgate, HF Botfield, Z Alimajstorovic… - JCI insight, 2021 - ncbi.nlm.nih.gov
BACKGROUND Idiopathic intracranial hypertension (IIH) is a condition predominantly
affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease …

Association between idiopathic intracranial hypertension and risk of cardiovascular diseases in women in the United Kingdom

NJ Adderley, A Subramanian… - JAMA …, 2019 - jamanetwork.com
Importance Cardiovascular disease (CVD) risk has not been previously evaluated in a large
matched cohort study in idiopathic intracranial hypertension (IIH). Objectives To estimate the …

Association of amount of weight lost after bariatric surgery with intracranial pressure in women with idiopathic intracranial hypertension

SP Mollan, JL Mitchell, A Yiangou, RS Ottridge… - Neurology, 2022 - AAN Enterprises
Background and Objectives The idiopathic intracranial hypertension randomized controlled
weight trial (IIH: WT) established that weight loss through bariatric surgery significantly …

Headache attributed to idiopathic intracranial hypertension and persistent Post‐Idiopathic intracranial hypertension headache: a narrative review

SP Mollan, O Grech, AJ Sinclair - … The Journal of Head and Face …, 2021 - Wiley Online Library
Objective Headache is a near‐universal sequela of idiopathic intracranial hypertension (IIH).
The aim of this paper is to report current knowledge of headache in IIH and to identify …

Idiopathic intracranial hypertension: evaluation of admissions and emergency readmissions through the hospital episode statistic dataset between 2002–2020

SP Mollan, J Mytton, G Tsermoulas, AJ Sinclair - Life, 2021 - mdpi.com
With increasing incidence and prevalence of Idiopathic intracranial hypertension in the UK,
the aim of this study was to explore emerging themes in Idiopathic intracranial hypertension …

Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus

SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2024 - Springer
The principles of cerebrospinal fluid (CSF) production, circulation and outflow and regulation
of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these …

An update on idiopathic intracranial hypertension in adults: a look at pathophysiology, diagnostic approach and management

S Toscano, S Lo Fermo, E Reggio, CG Chisari… - Journal of …, 2021 - Springer
Idiopathic intracranial hypertension is a neurological syndrome determined by a rise in
intracranial pressure without a detectable cause. Course and prognosis may be …

11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in idiopathic intracranial hypertension

RS Hardy, H Botfield, K Markey… - The Journal of …, 2021 - academic.oup.com
Background The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
determines prereceptor metabolism and activation of glucocorticoids within peripheral …