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Molecular rotors: Fluorescent sensors for microviscosity and conformation of biomolecules
M Paez‐Perez, MK Kuimova - Angewandte Chemie, 2024 - Wiley Online Library
The viscosity and crowding of biological environment are considered vital for the correct
cellular function, and alterations in these parameters are known to underly a number of …
cellular function, and alterations in these parameters are known to underly a number of …
The essential functions of molecular chaperones and folding enzymes in maintaining endoplasmic reticulum homeostasis
LM Hendershot, TM Buck, JL Brodsky - Journal of Molecular Biology, 2024 - Elsevier
It has been estimated that up to one-third of the proteins encoded by the human genome
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …
Polysome collapse and RNA condensation fluidize the cytoplasm
Y **e, T Shu, T Liu, MC Spindler, J Mahamid… - Molecular Cell, 2024 - cell.com
The cell interior is packed with macromolecules of mesoscale size, and this crowded milieu
significantly influences cellular physiology. Cellular stress responses almost universally lead …
significantly influences cellular physiology. Cellular stress responses almost universally lead …
ER‐to‐lysosome‐associated degradation in a nutshell: mammalian, yeast, and plant ER‐phagy as induced by misfolded proteins
M Rudinskiy, M Molinari - FEBS letters, 2023 - Wiley Online Library
Conserved catabolic pathways operate to remove aberrant polypeptides from the
endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best …
endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best …
α-Synuclein: Multiple pathogenic roles in trafficking and proteostasis pathways in Parkinson's disease
AJ Zalon, DJ Quiriconi, C Pitcairn… - The …, 2024 - journals.sagepub.com
Parkinson's disease (PD) is a common age-related neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the midbrain. A hallmark of both …
characterized by the loss of dopaminergic neurons in the midbrain. A hallmark of both …
Protein quality control and aggregation in the endoplasmic reticulum: From basic to bedside
G Chen, T Wei, F Ju, H Li - Frontiers in cell and developmental biology, 2023 - frontiersin.org
Endoplasmic reticulum (ER) is the largest membrane-bound compartment in all cells and
functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance …
functions as a key regulator in protein biosynthesis, lipid metabolism, and calcium balance …
Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD
Z Song, P Thepsuwan, WS Hur, M Torres… - Nature …, 2024 - nature.com
Impaired secretion of an essential blood coagulation factor fibrinogen leads to hepatic
fibrinogen storage disease (HFSD), characterized by the presence of fibrinogen-positive …
fibrinogen storage disease (HFSD), characterized by the presence of fibrinogen-positive …
Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …